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Buongiorno <<Nome>>
Rassegna stampa ematologica
a cura di Giulio D'Alfonso

numero 4 / 2022
3 febbraio 2022
Consigliati per voi questa settimana  
GUIDELINES
 
REVIEWS
 
Diagnosis and Management of Multiple Myeloma: A Review
 • JAMA – Andrew J. Cowan et al.

Consensus guidelines and recommendations for infection prevention in multiple myeloma: a report from the International Myeloma Working Group  • The Lancet Haematology 

Integrating genetic and epigenetic factors in chronic myeloid leukemia risk assessment: toward gene expression-based biomarkers (729 Online Views)
• Haematologica – Vaidehi Krishnan et al.

Pre‐treatment total metabolic tumour volumes in lymphoma: Does quantity matter? • BJH – Tarec Christoffer El-Galaly et al.

Advances in treatment of elderly primary central nervous system lymphoma • BJH – Nicolas Martinez-Calle et al.

The evolving status of immunotherapies in multiple myeloma: the future role of bispecific antibodies • BJH – Dawn Swan et al.

Betibeglogene Autotemcel Gene Therapy for Non–β0/β0 Genotype β-Thalassemia


F. Locatelli et al.

The new England journal of Medicine
Gli articoli di questa settimana
Association of AZD1222 and BNT162b2 COVID-19 Vaccination With Thromboembolic and Thrombocytopenic Events in Frontline Personnel
BLOOD COMMENTARIES 
 
 
 
Sustained minimal residual disease in myeloma  
 
Giada Bianchi
 
Blood January 2022, Vol.139, 469-471. doi: 10.1182/blood.2021013199
 
 
Proton export takes charge of proliferation  
 
Stephanie Z. Xie
 
Blood January 2022, Vol.139, 471-473. doi: 10.1182/blood.2021014237
 
 
Increasing CART cell engine performance in CLL  
 
Fleur S. PetersArnon P. Kater
 
Blood January 2022, Vol.139, 473-474. doi: 10.1182/blood.2021013895
 
 
Metabolic path toward TCF3 inactivation in Burkitt lymphoma  
 
Ulf Klein
 
Blood January 2022, Vol.139, 475-476. doi: 10.1182/blood.2021014133
 
 
A Micro-lyse goes a long way  
 
Colin A. Kretz
 
Blood January 2022, Vol.139, 477-479. doi: 10.1182/blood.2021014618
 
 
A glimpse into what happens after PTCy  
 
Mark Leick ; Yi-Bin Chen
 
Blood January 2022, Vol.139, 479-481. doi: 10.1182/blood.2021014264
 
 
Patience is a virtue  
 
Carl R. Walkley
 
Blood January 2022, Vol.139, 481-482. doi: 10.1182/blood.2021014427
 
 
REVIEW ARTICLE 
 
 
 
The bone marrow niche from the inside out: how megakaryocytes are shaped by and shape hematopoiesis  
 
Andrew P. StoneThais F. NascimentoMaria N. Barrachina
 
Blood January 2022, Vol.139, 483-491. doi: 10.1182/blood.2021012827
 
 
CLINICAL TRIALS AND OBSERVATIONS 
 
 
 
Sustained minimal residual disease negativity in newly diagnosed multiple myeloma and the impact of daratumumab in MAIA and ALCYONE  
 
Jesus San-MiguelHervé Avet-LoiseauBruno Paiva ; Shaji KumarMeletios A. DimopoulosThierry FaconMaría-Victoria MateosCyrille TouzeauAndrzej JakubowiakSaad Z. UsmaniGordon CookMichele CavoHang QuachJon UkropecPriya RamaswamiHuiling PeiMia QiSteven Sun ; Jianping WangMaria KrevvataNikki DeAngelisChristoph HeuckRian Van Rampelbergh ; Anupa KudvaRachel KobosMing QiNizar J. Bahlis
 
Blood January 2022, Vol.139, 492-501. doi: 10.1182/blood.2020010439
 
 
HEMATOPOIESIS AND STEM CELLS 
 
 
 
Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth  
 
Cheuk Him ManFrancois E. MercierNian LiuWentao DongGregory StephanopoulosLi JiangYookyung JungCharles P. LinAnskar Y. H. LeungDavid T. Scadden
 
Blood January 2022, Vol.139, 502-522. doi: 10.1182/blood.2021011563
 
 
IMMUNOBIOLOGY AND IMMUNOTHERAPY 
 
 
 
PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity  
 
Christopher Ronald Funk ; Shuhua WangKevin Z. ChenAlexandra WallerAditi SharmaClaudia L. Edgar ; Vikas A. GuptaShanmuganathan ChandrakasanJaquelyn T. ZoineAndrew FedanovSunil S. RaikarJean L. KoffChristopher R. FlowersSilvia ComaJonathan A. PachterSruthi RavindranathanH. Trent SpencerMala ShanmugamEdmund K. Waller
 
Blood January 2022, Vol.139, 523-537. doi: 10.1182/blood.2021011597
 
 
LYMPHOID NEOPLASIA 
 
 
 
SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma  
 
Anne C. WilkeCarmen DoebeleAlena ZindelKwang Seok LeeSara A. Rieke ; Michele CeribelliFederico ComoglioJames D. PhelanJames Q. WangYana Pikman ; Dominique JahnBjörn HäuplConstanze SchneiderSebastian ScheichFrances A. TostoHanibal BohnenbergerPhilipp StauderFrank SchnütgenMikolaj Slabicki ; Zana A. CoulibalySebastian WolfKamil BojarczukBjörn ChapuyChristian H. BrandtsPhilipp StroebelCaroline A. LewisMichael EngelkeXincheng XuHahn KimThanh Hung DangRoland SchmitzDaniel J. HodsonKimberly StegmaierHenning UrlaubHubert ServeClemens A. SchmittFernando KreuzGero KnittelJoshua D. RabinowitzHans Christian ReinhardtMatthew G. Vander HeidenCraig ThomasLouis M. Staudt ; Thorsten ZenzThomas Oellerich
 
Blood January 2022, Vol.139, 538-553. doi: 10.1182/blood.2021012081
 
 
PEG10 amplification at 7q21.3 potentiates large-cell transformation in cutaneous T-cell lymphoma  
 
Fengjie LiuYumei GaoBufang XuShan XiongShengguo Yi ; Jingru SunZhuojing ChenXiangjun LiuYingyi LiYuchieh Lin ; Yujie WenYao QinShuxia YangHang LiTrilokraj TejasviLam TsoiPing TuXianwen RenYang Wang
 
Blood January 2022, Vol.139, 554-571. doi: 10.1182/blood.2021012091
 
 
MYELOID NEOPLASIA 
 
 
 
Frequency and prognostic impact of blood-circulating tumor mast cells in mastocytosis  
 
Ana HenriquesJavier I. Muñoz-GonzálezLaura Sánchez-Muñoz ; Almudena MatitoLidia Torres-RiveraMaría Jara-AcevedoCarolina CaldasAndrea MayadoAlba Pérez-PonsAndrés C. García-MonteroIván Álvarez-TwoseAlberto Orfao
 
Blood January 2022, Vol.139, 572-583. doi: 10.1182/blood.2021012694
 
 
The STAT3-MYC axis promotes survival of leukemia stem cells by regulating SLC1A5 and oxidative phosphorylation  
 
Maria L. AmayaAnagha Inguva ; Shanshan PeiCourtney JonesAnna KrugHaobin YeMohammad Minhajuddin ; Amanda WintersSteffanie L. FurtekFabia GamboniBrett StevensAngelo D’Alessandro ; Daniel A. PollyeaPhilip ReiganCraig T. Jordan
 
Blood January 2022, Vol.139, 584-596. doi: 10.1182/blood.2021013201
 
 
THROMBOSIS AND HEMOSTASIS 
 
 
 
Microlyse: a thrombolytic agent that targets VWF for clearance of microvascular thrombosis  
 
Steven de MaatChantal C. ClarkArjan D. BarendrechtSimone SmitsNadine D. van Kleef ; Hinde El OtmaniManon WaningMarc van MoorselMichael SzardeningsNicolas Delaroque ; Kristof VercruysseRolf T. UrbanusSilvie SebastianPeter J. LentingChristoph HagemeyerThomas RennéKaren VanhoorelbekeClaudia TersteegCoen Maas
 
Blood January 2022, Vol.139, 597-607. doi: 10.1182/blood.2021011776
 
 
TRANSPLANTATION 
 
 
 
Signatures of GVHD and relapse after posttransplant cyclophosphamide revealed by immune profiling and machine learning  
 
Shannon R. McCurdyVedran RadojcicHua-Ling Tsai ; Ante VulicElizabeth ThompsonSanja IvcevicChristopher G. KanakryJonathan D. PowellBrian LohmanDjamilatou AdomSophie PaczesnyKenneth R. CookeRichard J. JonesRavi VaradhanHeather J. SymonsLeo Luznik
 
Blood January 2022, Vol.139, 608-623. doi: 10.1182/blood.2021013054
 
 
LETTERS TO BLOOD 
 
 
 
Neutrophil and platelet increases with luspatercept in lower-risk MDS: secondary endpoints from the MEDALIST trial  
 
Guillermo Garcia-ManeroGhulam J. MuftiPierre FenauxRena BucksteinValeria Santini ; María Díez-CampeloCarlo FinelliOsman IlhanMikkael A. SekeresAmer M. ZeidanRodrigo ItoJennie ZhangAnita RampersadDaniel SinsimerJay T. BackstromUwe PlatzbeckerRami S. Komrokji
 
Blood January 2022, Vol.139, 624-629. doi: 10.1182/blood.2021012589
 
 
Aged healthy mice acquire clonal hematopoiesis mutations  
 
Desmond Wai Loon ChinTetsuichi YoshizatoStina Virding CulletonFrancesca GrassoMagdalena BarbachowskaSeishi OgawaSten Eirik W. JacobsenPetter S. Woll
 
Blood January 2022, Vol.139, 629-634. doi: 10.1182/blood.2021014235
 
 
BLOOD WORK 
 
 
 
Fibrin-associated diffuse large B-cell lymphoma with aberrant CD4 expression  
 
Hamza TariqUrooj Zahra
 
Blood January 2022, Vol.139, 635. doi: 10.1182/blood.2021013959

ISSUE INFORMATION

Free AccessIssue Information

Pages: 457-460 | First Published:25 January 2022

 

IMAGES

Idiopathic multicentric Castleman disease of TAFRO subtype
Katherine Godfrey, Emma Harris, Hilary Moss, Pedro Martin-Cabrera

Pages: 461 | First Published:07 October 2021

Double‐hit multiple myeloma with atypical “faggot” cells
Orancie Alcouffe, Vincent Mémier, Frederique Dubois-Galopin, Aurore Perrot, Jill Corre, Jean-Baptiste Rieu

Pages: 462 | First Published:07 October 2021

Intra‐ and extracellular crystal deposition in a case of amyloid light chain amyloidosis
Christopher G. Mullen, Sarah E. Clarke, Tamasin Doig, Victoria L. Campbell

Pages: 463 | First Published:13 November 2021

 

COMMENTARIES

Laboratory diagnosis of iron deficiency: look out for the ‘PITTs’
Deborah Rund

Pages: 464-465 | First Published:24 October 2021

T cells to the rescue?
Jeremy Pantin, Minoo Battiwalla

Pages: 466-467 | First Published:25 October 2021


Open Access
Epstein–Barr virus positivity as a defining pathogenetic feature of Burkitt lymphoma subtypes
Lorenzo Leoncini

Pages: 468-470 | First Published:02 November 2021


Free Access
Is COVID‐19 less severe in CML patients than in those with other haematological cancers?
Simone Claudiani

Pages: 471-472 | First Published:27 October 2021

 

REVIEWS

Advances in treatment of elderly primary central nervous system lymphoma
Nicolas Martinez-Calle, Lisa K. Isbell, Kate Cwynarski, Elisabeth Schorb

Pages: 473-487 | First Published:26 August 2021


Open Access
The evolving status of immunotherapies in multiple myeloma: the future role of bispecific antibodies
Dawn Swan, David Routledge, Simon Harrison

Pages: 488-506 | First Published:01 September 2021

 

GUIDELINES

Free Access
Guidelines for the management of mature T‐ and natural killer‐cell lymphomas (excluding cutaneous T‐cell lymphoma): a British Society for Haematology Guideline
Christopher P. Fox, Matthew J. Ahearne, Ruth Pettengell, Claire Dearden, Dima El-Sharkawi, Shireen Kassam, Lucy Cook, Kate Cwynarski, Tim Illidge, Graham Collins

Pages: 507-522 | First Published:22 November 2021


Free Access
Guideline for the laboratory diagnosis of iron deficiency in adults (excluding pregnancy) and children
Andrew Fletcher, Adam Forbes, Nicola Svenson, D. Wayne Thomas, on behalf of and A British Society for Haematology Good Practice Paper 

Pages: 523-529 | First Published:24 October 2021

 

GLOBAL PERSPECTIVES

Open Access
Precursor B‐cell acute lymphoblastic leukaemia—a global view
Andrea Biondi, Valentino Conter, Mammen Chandy, Primus Ewald, Marie Lucia de Martino Lee, Vivek S. Radhakrishnan, Wannaphorn Rotchanapanya, Patricia Scanlan, Owen Patrick Smith, Boubacar Togo, Peter Hokland

Pages: 530-547 | First Published:20 December 2021

 

COVID-19

Open Access
T‐cell immune response after mRNA SARS‐CoV‐2 vaccines is frequently detected also in the absence of seroconversion in patients with lymphoid malignancies
Vincenzo Marasco, Cristiana Carniti, Anna Guidetti, Lucia Farina, Martina Magni, Rosalba Miceli, Ludovica Calabretta, Paolo Verderio, Silva Ljevar, Fabio Serpenti, Daniele Morelli, Giovanni Apolone, Giuseppe Ippolito, Chiara Agrati, Paolo Corradini

Pages: 548-558 | First Published:14 October 2021


Free Access
COVID‐19 infection in chronic myeloid leukaemia after one year of the pandemic in Italy. A Campus CML report
Massimo Breccia, Elisabetta Abruzzese, Vincenzo Accurso, Immacolata Attolico, Sara Barulli, Micaela Bergamaschi, Gianni Binotto, Monica Bocchia, Massimiliano Bonifacio, Giovanni Caocci, Isabella Capodanno, Fausto Castagnetti, Francesco Cavazzini, Elena Crisà, Monica Crugnola, Maria Stella De Candia, Chiara Elena, Carmen Fava, Sara Galimberti, Antonella Gozzini, Gabriele Gugliotta, Tamara Intermesoli, Alessandra Iurlo, Gaetano La Barba, Roberto Latagliata, Sabrina Leonetti Crescenzi, Luciano Levato, Giuseppina Loglisci, Alessandro Lucchesi, Luigiana Luciano, Francesca Lunghi, Debora Luzi, Alessandra Malato, Maria Cristina Miggiano, Michele Pizzuti, Patrizia Pregno, Davide Rapezzi, Giovanna Rege-Cambrin, Gianantonio Rosti, Sabina Russo, Rosaria Sancetta, Anna Rita Scortechini, Federica Sorà, Paolo Sportoletti, Fabio Stagno, Agostino Tafuri, Mario Tiribelli, Robin Foà, Giuseppe Saglio

Pages: 559-565 | First Published:11 October 2021


Free Access
Impact of major bleeding and thrombosis on 180‐day survival in patients with severe COVID‐19 supported with veno‐venous extracorporeal membrane oxygenation in the United Kingdom: a multicentre observational study
Deepa J. Arachchillage, Indika Rajakaruna, Ian Scott, Mihaela Gaspar, Zain Odho, Winston Banya, Aikaterini Vlachou, Graziella Isgro, Lenka Cagova, Joshua Wade, Lucy Fleming, Mike Laffan, Richard Szydlo, Stephane Ledot, Rachel Jooste, Alain Vuylsteke, Hakeem Yusuff

Pages: 566-576 | First Published:07 October 2021

 

SHORT REPORTS

Free Access
Efficacy and safety of heterologous booster vaccination with Ad26.COV2.S after BNT162b2 mRNA COVID‐19 vaccine in haemato‐oncological patients with no antibody response
Patrick Reimann, Hanno Ulmer, Beatrix Mutschlechner, Magdalena Benda, Luciano Severgnini, Andreas Volgger, Theresia Lang, Michele Atzl, Minh Huynh, Klaus Gasser, Claudia Grabher, Sylvia Mink, Peter Fraunberger, Ulf Petrausch, Bernd Hartmann, Thomas Winder

Pages: 577-584 | First Published:06 December 2021

 

CORRESPONDENCE-COVID-19

Free Access
Refusing blood transfusions from COVID‐19‐vaccinated donors: are we repeating history?
Jeremy W. Jacobs, Lorin A. Bibb, Bipin N. Savani, Garrett S. Booth

Pages: 585-588 | First Published:15 September 2021

 

CORRESPONDENCE-COVID-19–ONLINE ONLY

Free Access
Serological response to the BNT162b2 mRNA or ChAdOx1 nCoV‐19 COVID‐19 vaccine after first and second doses in patients with plasma cell disorders: influence of host and disease factors
Wei Yee Chan, Lara Howells, William Wilson, Emilie Sanchez, Louise Ainley, Selina J. Chavda, Emma Dowling, Nuno Correia, Catherine S. Y. Lecat, Annabel McMillan, Brendan Wisniowski, Shameem Mahmood, Xenofon Papanikolaou, Lydia Lee, Jonathan Sive, Charalampia Kyriakou, Ashutosh Wechalekar, Rakesh Popat, Neil Rabin, Eleni Nastouli, Kwee L. Yong, Ke Xu

Pages: e21-e26 | First Published:10 October 2021

 

HAEMATOLOGICAL MALIGNANCY–CLINICAL

Revised International Prognostic Index and genetic alterations are associated with early failure to R‐CHOP in patients with diffuse large B‐cell lymphoma
Ivan Dlouhy, Kennosuke Karube, Anna Enjuanes, Itziar Salaverria, Ferran Nadeu, Juan Enric Ramis-Zaldivar, Juan G. Valero, Alfredo Rivas-Delgado, Laura Magnano, David Martin-García, Patricia Pérez-Galán, Guillem Clot, Jordina Rovira, Pedro Jares, Olga Balagué, Eva Giné, Pablo Mozas, Javier Briones, Juan-Manuel Sancho, Antonio Salar, Santiago Mercadal, Miguel Alcoceba, Alexandra Valera, Elías Campo, Armando López-Guillermo

Pages: 589-598 | First Published:10 October 2021

Characteristics of thrombocytopenia, anasarca, fever, reticulin fibrosis and organomegaly syndrome: a retrospective study from a large Western cohort
Lucas Maisonobe, Rémi Bertinchamp, Louise Damian, Laurence Gérard, Mirlinda Berisha, Stéphanie Guillet, Claire Fieschi, Marion Malphettes, Jehane Fadlallah, Miguel Hié, Bertrand Dunogué, Virginie De Wilde, Frédéric Vandergheynst, Lara Zafrani, Maximilien Grall, Noémie Saada, Margaux Garzaro, Eric Oksenhendler, Lionel Galicier, David Boutboul

Pages: 599-605 | First Published:28 September 2021


Open Access
Reinduction therapy with everolimus in combination with dexamethasone, high‐dose cytarabin and cisplatinum in patients with relapsed or refractory classical Hodgkin lymphoma: an experimental phase I/II multicentre trial of the German Hodgkin Study Group (GHSG HD‐R3i)
Sarah Gillessen, Andreas Hüttmann, Vladan Vucinic, Horst Müller, Annette Plütschow, Andreas Viardot, Max S. Topp, Carsten Kobe, Boris Böll, Dennis A. Eichenauer, Stephanie Sasse, Heinz Haverkamp, Christine Schmitz, Sven Borchmann, Paul J. Bröckelmann, Jan-Michel Heger, Michael Fuchs, Andreas Engert, Peter Borchmann, Bastian von Tresckow

Pages: 606-616 | First Published:14 November 2021

Tracking the evolution of untreated high‐intermediate/high‐risk diffuse large B‐cell lymphoma by circulating tumour DNA
Sicong Zhang, Tingting Zhang, Hengqi Liu, Jing Zhao, Haifei Zhou, Xiaoxing Su, Xianming Liu, Lanfang Li, Lihua Qiu, Zhengzi Qian, Shiyong Zhou, Wenchen Gong, Bin Meng, Xiubao Ren, Jin He, Xianhuo Wang, Huilai Zhang

Pages: 617-628 | First Published:19 October 2021


Open Access
Clinical significance of the immunoglobulin G heavy‐chain repertoire in peripheral blood mononuclear cells of adult T‐cell leukaemia–lymphoma patients receiving mogamulizumab
Kisato Nosaka, Shigeru Kusumoto, Nobuaki Nakano, Ilseung Choi, Makoto Yoshimitsu, Yoshitaka Imaizumi, Michihiro Hidaka, Hidenori Sasaki, Junya Makiyama, Eiichi Ohtsuka, Tatsuro Jo, Masao Ogata, Asahi Ito, Kentaro Yonekura, Hiro Tatetsu, Takeharu Kato, Toshiro Kawakita, Youko Suehiro, Kenji Ishitsuka, Shinsuke Iida, Takaji Matsutani, Atae Utsunomiya, Ryuzo Ueda, Takashi Ishida

Pages: 629-638 | First Published:10 October 2021


Open Access
Patient‐reported outcomes in relapsed/refractory multiple myeloma treated with melflufen plus dexamethasone: analyses from the Phase II HORIZON study
Alessandra Larocca, Xavier Leleu, Cyrille Touzeau, Joan Bladé, Agne Paner, María-Victoria Mateos, Michele Cavo, Christopher Maisel, Adrían Alegre, Albert Oriol, Anastasios Raptis, Paula Rodriguez-Otero, Amitabha Mazumder, Jacob Laubach, Omar Nadeem, Anna Sandberg, Marie Orre, Anna Torrång, Nicolaas A. Bakker, Paul G. Richardson

Pages: 639-648 | First Published:21 October 2021

Real‐world data on survival improvement in patients with multiple myeloma treated at a single institution over a 45‐year period
Luis Gerardo Rodríguez-Lobato, Arturo Pereira, Carlos Fernández de Larrea, Maria Teresa Cibeira, Natalia Tovar, Raquel Jiménez-Segura, David F. Moreno, Aina Oliver-Caldés, Laura Rosiñol, Joan Bladé

Pages: 649-659 | First Published:07 October 2021


Open Access
Primary therapy and relative survival in patients with lymphoplasmacytic lymphoma/Waldenström macroglobulinaemia: a population‐based study in the Netherlands, 1989–2018
Karima Amaador, Marie José Kersten, Otto Visser, Mirian Brink, Eduardus F. M. Posthuma, Monique C. Minnema, Josephine M. I. Vos, Avinash G. Dinmohamed

Pages: 660-669 | First Published:03 October 2021

 

SHORT REPORTS

Open Access
Prognostic heterogeneity of adult B‐cell precursor acute lymphoblastic leukaemia patients with t(1;19)(q23;p13)/TCF3‐PBX1 treated with measurable residual disease‐oriented protocols
Jordi Ribera, Isabel Granada, Mireia Morgades, Teresa González, Juana Ciudad, Esperanza Such, María-José Calasanz, Santiago Mercadal, Rosa Coll, José González-Campos, Mar Tormo, Irene García-Cadenas, Cristina Gil, Marta Cervera, Pere Barba, Dolors Costa, Rosa Ayala, Arancha Bermúdez, Alberto Orfao, Josep-Maria Ribera, on behalf of the Programa para el Tratamiento de Hemopatias Malignas (PETHEMA) Group (Spanish Society of Hematology, SEHH) 

Pages: 670-675 | First Published:21 September 2021

Revisiting Diagnostic performances of serum erythropoïetin level and JAK2 mutation for polycythemias: analysis of a cohort of 1090 patients with red cell mass measurement
Nabih Maslah, Odonchimeg Ravdan, Louis Drevon, Emmanuelle Verger, Célia Belkhodja, Christine Chomienne, Bruno Cassinat, Jean-Jacques Kiladjian, Stéphane Giraudier, Marie-Hélène Schlageter

Pages: 676-680 | First Published:25 September 2021

 

HAEMATOLOGICAL MALIGNANCY–BIOLOGY

Open Access
Epstein–Barr virus status of sporadic Burkitt lymphoma is associated with patient age and mutational features
Julia Richter, Katharina John, Annette M. Staiger, Andreas Rosenwald, Katrin Kurz, Ulf Michgehl, German Ott, Sören Franzenburg, Christian Kohler, Jasmin Finger, Ilske Oschlies, Ulrike Paul, Reiner Siebert, Rainer Spang, Birgit Burkhardt, Wolfram Klapper

Pages: 681-689 | First Published:06 October 2021


Open Access
Use of dipyridamole is associated with lower risk of lymphoid neoplasms: a propensity score‐matched cohort study
Wuqing Huang, Kristina Sundquist, Jan Sundquist, Jianguang Ji

Pages: 690-699 | First Published:23 September 2021

 

SHORT REPORTS

Identification of a novel GOLGA4–JAK2 fusion gene in B‐cell acute lymphoblastic leukaemia
Charlotte E. J. Downes, Jacqueline Rehn, Susan L. Heatley, David Yeung, Barbara J. McClure, Deborah L. White

Pages: 700-705 | First Published:25 October 2021

Low levels of minimal residual disease after induction chemotherapy for BCR‐ABL1‐negative acute lymphoblastic leukaemia in adults are clinically relevant
Cyril Šálek, František Folber, Eva Froňková, Pavla Pecherková, Hana Jelínková, Štěpán Hrabovský, Jan M. Horáček, Petr Cetkovský, Jiří Mayer, Jan Trka, Michael Doubek, for the Czech Leukemia Study Group – for Life (CELL) 

Pages: 706-710 | First Published:23 November 2021

 

TRANSPLANTATION

Open Access
Identification of the minimum requirements for successful haematopoietic stem cell transplantation
Katsuyuki Nishi, Taro Sakamaki, Kay Sadaoka, Momo Fujii, Akifumi Takaori-Kondo, James Y. Chen, Masanori Miyanishi

Pages: 711-723 | First Published:20 December 2021

Impact of donor telomere length on survival in patients undergoing matched sibling donor transplantation for aplastic anaemia
Aruna Barade, Fouzia Aboobacker, Anu Korula, Kavitha Lakshmi, Anup Devasia, Aby Abraham, Vikram Mathews, Eunice Edison, Biju George

Pages: 724-734 | First Published:03 October 2021

Development and validation of a mortality predicting scoring system for severe aplastic anaemia patients receiving haploidentical allogeneic transplantation
Lan-Ping Xu, Yu Yu, Yi-Fei Cheng, Yuan-Yuan Zhang, Xiao-Dong Mo, Ting-Ting Han, Feng-Rong Wang, Chen-Hua Yan, Yu-Qian Sun, Yu-Hong Chen, Jing-Zhi Wang, Zheng-Li Xu, Fei-Fei Tang, Wei Han, Yu Wang, Xiao-Hui Zhang, Xiao-Jun Huang

Pages: 735-742 | First Published:06 November 2021

 

PAEDIATRICS

Superior outcomes with paediatric protocols in adolescents and young adults with aggressive B‐cell non‐Hodgkin lymphoma
Sumit Gupta, Sarah Alexander, Jason D. Pole, Rinku Sutradhar, Michael Crump, Chenthila Nagamuthu, Nancy N. Baxter, Paul C. Nathan

Pages: 743-752 | First Published:01 October 2021


Open Access
Genetic characterisation of childhood B‐other‐acute lymphoblastic leukaemia in UK patients by fluorescence in situ hybridisation and Multiplex Ligation‐dependent Probe Amplification
Claire J. Schwab, Daniel Murdy, Ellie Butler, Amir Enshaei, Emily Winterman, Ruth E. Cranston, Sarra Ryan, Emilio Barretta, Zoe Hawking, James Murray, Grace Antony, Ajay Vora, Anthony V. Moorman, Christine J. Harrison

Pages: 753-763 | First Published:21 October 2021

 

SHORT REPORTS

Using the in vitro drug sensitivity test to identify candidate treatments for transient abnormal myelopoiesis
Tomoko Yokosuka, Mieko Ito, Yuki Yoshino, Ayana Hirose, Wataru Nakamura, Yukari Sakurai, Akiko Hayashi, Sachio Fujita, Naoyuki Miyagawa, Dai Keino, Fuminori Iwasaki, Satoshi Hamanoue, Masakatsu Yanagimachi, Shoko Goto, Jun-ichi Nagai, Hiroo Ueno, Junko Takita, Yukichi Tanaka, Takashi Taga, Hiroaki Goto

Pages: 764-768 | First Published:23 November 2021

 

HAEMOGLOBINOPATHIES

Open Access
Extended phenotyping does not preclude the occurrence of delayed haemolytic transfusion reactions in sickle cell disease
Jorn Gerritsma, Vera Bongaerts, Corien Eckhardt, Harriet Heijboer, Erfan Nur, Bart Biemond, Ellen van der Schoot, Karin Fijnvandraat, on behalf of SCORE consortium 

Pages: 769-776 | First Published:10 October 2021

 

SHORT REPORTS

Intestinal pathophysiological abnormalities in steady state and after vaso‐occlusive crisis in murine sickle cell disease
Maria Poplawska, Dibyendu Dutta, Manjunath Jayaram, Moro Salifu, Ngee S. Chong, Seah H. Lim

Pages: 777-780 | First Published:10 October 2021

 

LETTERS TO THE EDITOR

Free Access
Baseline creatinine predicts acute kidney injury during intensive therapy in transplant‐eligible patients with acute myeloid leukaemia
Stefan Krieg, Harald Seeger, Patrick Hofmann, Carmen Del Prete, Markus G. Manz, Antonia M. Müller, Alexandre P. A. Theocharides

Pages: 781-784 | First Published:05 October 2021


Free Access
Chronic lymphocytic leukaemia clones are detectable decades before diagnosis
Fie J. Vojdeman, Jens Helby, Lone B. Pedersen, Christian Brieghel, Michael A. Andersen, Børge G. Nordestgaard, Stig E. Bojesen, Carsten U. Niemann

Pages: 784-787 | First Published:27 September 2021


Free Access
Poly(ADP‐ribose)polymerase inhibitors‐associated myeloid neoplasms: a retrospective study from the French Network of Pharmacovigilance centres
Pierre-Marie Morice, Alexis Genthon, Thomas Boyer, Kevin Bihan, Julien Mahé, Anthony Sourisseau, Hélène Peyrouzet, Ghada Miremont, Marion Lepelley, Laetitia Stefani, Louise Gaboriau, Fanny Rocher, Danièle Aquaronne, Christine Le Beller, Marion Allouchery, Brahim Azzouz, Nathalie Massy, Martine Alt-Tebacher, Célestine Simand, Raoul Herbrecht, Basile Chrétien, Charles Dolladille, Sylvain Chantepie, Joachim Alexandre

Pages: 787-793 | First Published:05 October 2021

 

LETTERS TO THE EDITOR – ONLINE ONLY

Free Access
Convalescent plasma and remdesivir for protracted COVID‐19 in a patient with chronic lymphocytic leukaemia: a case report of late relapse after rapid initial response
Carla Schenker, Cédric Hirzel, Laura N. Walti, Sacha S. Zeerleder, Martin Andres, Alban Ramette, Maria T. Barbani, Franziska Suter-Riniker, Andreas Holbro, Tobias Tritschler

Pages: e27-e29 | First Published:30 August 2021


Free Access
First use of the anti‐VWF nanobody caplacizumab to treat iTTP in pregnancy
Lucas Kühne, Linus A. Völker, Henning Hagmann, Holger Hägele, Thomas Osterholt, Dennis A. Eichenauer, Andreas Thomas, Johanna Breuer, Berthold Grüttner, Ingo Gottschalk, Martin Kann, Thomas Benzing, Mario Thevis, Annette M. Müller, Paul T. Brinkkoetter

Pages: e30-e33 | First Published:29 September 2021


Free Access
Paediatric ambiguous lineage leukaemia with monocytic differentiation at diagnosis: case series and review of literature
Sneha Tandon, Reginah Visser, Emma Astwood, Jeanette Payne, Juliet Gray, Lucy Wheeler, Julie Irving, Paul Virgo

Pages: e34-e39 | First Published:17 October 2021


Free Access
Autosomal dominant Shwachman–Diamond syndrome with a novel heterozygous missense variant in the SRP54 gene causing severe phenotypic features
Peter McCarthy, Melanie Cotter, Owen P. Smith

Pages: e39-e42 | First Published:22 September 2021


Free Access
Targeted treatment of immune thrombocytopenia in CTLA‐4 insufficiency: a case report
Chieh Min Benjamin Lai, Audi Setiadi, Angeliki Barlas, Amin Kanani, Persia Pourshahnazari, Heather A. Leitch, CAUSES Study , Daniel L. Metzger, Hayley Merkeley, Catherine M. Biggs


REVIEWS

Pre‐treatment total metabolic tumour volumes in lymphoma: Does quantity matter?
Tarec Christoffer El-Galaly, Diego Villa, Chan Yoon Cheah, Lars C. Gormsen

Version of Record online:17 January 2022

COMMENTARY

Everyone is entitled to his or her own opinion but not to their own facts*

Giovanni Barosi, Robert Peter Gale
 

ORIGINAL PAPER

Immune response to COVID‐19 vaccination is attenuated by poor disease control and antimyeloma therapy with vaccine driven divergent T cell response

Karthik Ramasamy, Ross Sadler, Sally Jeans, Paul Weeden, Sherin Varghese, Alison Turner, Jemma Larham, Nathanael Gray, Oluremi Carty, Joe Barrett, Stella Bowcock, Udo Oppermann, Gordon Cook, Chara Kyriakou, Mark Drayson, Supratik Basu, Sally Moore, Sarah McDonald, Sarah Gooding, Muhammad K Javaid

The impact of intestinal microbiota in antithymocyte globulin–based myeloablative allogeneic hematopoietic cell transplantation
Zhenyang Gu MD, PhD, Qian Xiong PhD, Lu Wang MD, Lili Wang PhD, Fei Li MD, Cheng Hou MD, Liping Dou MD, PhD, Baoli Zhu PhD, Daihong Liu MD, PhD

Version of Record online:25 January 2022

Gut dysbiosis in platforms of antithymocyte globulin–based myeloablative allogeneic hematopoietic stem cell transplantation featured loss of bacterial diversity. The diversity of the intestinal flora at the engraftment period was an independent predictor of longer survival.

ABOUT THE COVER
Images from the Haematologica Atlas of Hematologic Cytology: dyserythropoiesis (70 Online Views)

Rosangela Invernizzi

https://doi.org/10.3324/haematol.2021.280385

LANDMARK PAPERS IN HEMATOLOGY
The platelet aggregometer (27 Online Views)

Carlo L. Balduini

https://doi.org/10.3324/haematol.2021.280198

EDITORIALS

Too much and not enough: revisiting maintenance rituximab in indolent lymphomas (381 Online Views)

Sonali Smith

https://doi.org/10.3324/haematol.2021.279101

Efficacy and safety assessment of prolonged maintenance with subcutaneous rituximab in patients with relapsed or refractory indolent non-Hodgkin lymphoma: results of the phase III MabCute study

Simon Rule et al.

An exciting RXRA mutant revives interest in retinoids for acute myeloid leukemia (295 Online Views)

Fang Qiu, Hugues de The

https://doi.org/10.3324/haematol.2021.279152

RXRA DT448/9PP generates a dominant active variant capable of inducing maturation in acute myeloid leukemia cells

Orsola di Martino et al.

Are clinical pharmacology studies still needed in childhood acute lymphoblastic leukemia? (375 Online Views)

Valentino Conter, Francesco Ceppi

https://doi.org/10.3324/haematol.2021.279059

Comprehensive analysis of dose intensity of acute lymphoblastic leukemia chemotherapy

Seth E. Karol et al.
 

REVIEW ARTICLES
Integrating genetic and epigenetic factors in chronic myeloid leukemia risk assessment: toward gene expression-based biomarkers (729 Online Views)

Vaidehi Krishnan, Dennis Dong Hwan Kim, Timothy P. Hughes, Susan Branford, S. Tiong Ong

https://doi.org/10.3324/haematol.2021.279317

ARTICLES
Acute Lymphoblastic Leukemia

Comprehensive analysis of dose intensity of acute lymphoblastic leukemia chemotherapy (697 Online Views)

Seth E. Karol, Deqing Pei, Colton A. Smith, Yiwei Liu, Wenjian Yang, Nancy M. Kornegay, John C. Panetta, Kristine R. Crews, Cheng Cheng, Emily R. Finch, Hiroto Inaba, Monika L. Metzger, Jeffrey E. Rubnitz, Raul C. Ribeiro, Tanja A. Gruber, Jun J. Yang, William E. Evans, Sima Jeha, Ching-Hon Pui, Mary V. Relling

https://doi.org/10.3324/haematol.2021.278411
Hematopoiesis

Reversible switching of leukemic cells to a drug-resistant, stem-like subset via IL-4-mediated cross-talk with mesenchymal stroma (572 Online Views)

Hae-Ri Lee, Ga-Young Lee, Eung-Won Kim, Hee-Je Kim, Minho Lee, R. Keith Humphries, Il-Hoan Oh

https://doi.org/10.3324/haematol.2020.269944

Aging of human hematopoietic stem cells is linked to changes in Cdc42 activity (2069 Online Views)

Amanda Amoah, Anja Keller, Ramiz Emini, Markus Hoenicka, Andreas Liebold, Angelika Vollmer, Karina Eiwen, Karin Soller, Vadim Sakk, Yi Zheng, Maria Carolina Florian, Hartmut Geiger

https://doi.org/10.3324/haematol.2020.269670
Acute Myeloid Leukemia

APR-246 induces early cell death by ferroptosis in acute myeloid leukemia (2926 Online Views)

Rudy Birsen, Clement Larrue, Justine Decroocq, Natacha Johnson, Nathan Guiraud, Mathilde Gotanegre, Lilia Cantero-Aguilar, Eric Grignano, Tony Huynh, Michaela Fontenay, Olivier Kosmider, Patrick Mayeux, Nicolas Chapuis, Jean Emmanuel Sarry, Jerome Tamburini, Didier Bouscary

https://doi.org/10.3324/haematol.2020.259531

RXRA DT448/9PP generates a dominant active variant capable of inducing maturation in acute myeloid leukemia cells (481 Online Views)

Orsola di Martino, Margaret A. Ferris, Gayla Hadwiger, Soyi Sarkar, Anh Vu, María P. Menéndez-Gutiérrez, Mercedes Ricote, John S. Welch

https://doi.org/10.3324/haematol.2021.278603
Cell Therapy & Immunotherapy

Human invariant natural killer T cells promote tolerance by preferential apoptosis induction of conventional dendritic cells (688 Online Views)

Hannes Schmid, Emmanuelle M. Ribeiro, Kathy-Ann Secker, Silke Duerr-Stoerzer, Hildegard Keppeler, Ruoyun Dong, Timo Munz, Klaus Schulze-Osthoff, Stephan Hailfinger, Corina Schneidawind, Dominik Schneidawind

https://doi.org/10.3324/haematol.2020.267583

CD38 knockout natural killer cells expressing an affinity optimized CD38 chimeric antigen receptor successfully target acute myeloid leukemia with reduced effector cell fratricide (3291 Online Views)

Mark Gurney, Arwen Stikvoort, Emma Nolan, Lucy Kirkham-McCarthy, Stanislav Khoruzhenko, Rama Shivakumar, Sonja Zweegman, Niels W.C.J. van de Donk, Tuna Mutis, Eva Szegezdi, Subhashis Sarkar, Michael O’Dwyer

https://doi.org/10.3324/haematol.2020.271908

Successful gene therapy of Diamond-Blackfan anemia in a mouse model and human CD34+ cord blood hematopoietic stem cells using a clinically applicable lentiviral vector (1442 Online Views)

Yang Liu, Maria Dahl, Shubhranshu Debnath, Michael Rothe, Emma M. Smith, Tan Hooi Min Grahn, Sarah Warsi, Jun Chen, Johan Flygare, Axel Schambach, Stefan Karlsson

https://doi.org/10.3324/haematol.2020.269142
Complications in Hematology

Long term follow-up of pediatric-onset Evans syndrome: broad immunopathological manifestations and high treatment burden (858 Online Views)

Thomas Pincez, Helder Fernandes, Thierry Leblanc, Gérard Michel, Vincent Barlogis, Yves Bertrand, Bénédicte Neven, Wadih Abou Chahla, Marlène Pasquet, Corinne Guitton, Aude Marie-Cardine, Isabelle Pellier, Corinne Armari-Alla, Joy Benadiba, Pascale Blouin, Eric Jeziorski, Frédéric Millot, Catherine Paillard, Caroline Thomas, Nathalie Cheikh, Sophie Bayart, Fanny Fouyssac, Christophe Piguet, Marianna Deparis, Claire Briandet, Eric Dore, Capucine Picard, Frédéric Rieux-Laucat, Judith Landman-Parker, Guy Leverger, Nathalie Aladjidi

https://doi.org/10.3324/haematol.2020.271106
Iron Metabolism & its Disorders

Risk factors for endocrine complications in transfusion-dependent thalassemia patients on chelation therapy with deferasirox: a risk assessment study from a multi-center nation-wide cohort (968 Online Views)

Maddalena Casale, Gian Luca Forni, Elena Cassinerio, Daniela Pasquali, Raffaella Origa, Marilena Serra, Saveria Campisi, Angelo Peluso, Roberta Renni, Alessandro Cattoni, Elisa De Michele, Massimo Allò, Maurizio Poggi, Francesca Ferrara, Rosanna Di Concilio, Filomena Sportelli, Antonella Quarta, Maria Caterina Putti, Lucia Dora Notarangelo, Antonella Sau, Saverio Ladogana, Immacolata Tartaglione, Stefania Picariello, Alessia Marcon, Patrizia Sturiale, Domenico Roberti, Antonio Ivan Lazzarino, Silverio Perrotta

https://doi.org/10.3324/haematol.2020.272419

UBA6 and NDFIP1 regulate the degradation of ferroportin (629 Online Views)

Lisa Traeger, Steffen B. Wiegand, Andrew J. Sauer, Benjamin H.P. Corman, Kathryn M. Peneyra, Florian Wunderer, Anna Fischbach, Aranya Bagchi, Rajeev Malhotra, Warren M. Zapol, Donald B. Bloch

https://doi.org/10.3324/haematol.2021.278530
Non-Hodgkin Lymphoma

Early detection of T-cell lymphoma with T follicular helper phenotype by RHOA mutation analysis (1184 Online Views)

Rachel Dobson, Peter Y. Du, Lívia Rásó-Barnett, Wen-Qing Yao, Zi Chen, Calogero Casa, Hesham EI-Daly, Lorant Farkas, Elizabeth Soilleux, Penny Wright, John W. Grant, Manuel Rodriguez-Justo, George A. Follows, Hala Rashed, Margarete Fabre, E. Joanna Baxter, George Vassiliou, Andrew Wotherspoon, Ayoma D. Attygalle, Hongxiang Liu, Ming-Qing Du

https://doi.org/10.3324/haematol.2020.265991

Efficacy and safety assessment of prolonged maintenance with subcutaneous rituximab in patients with relapsed or refractory indolent non-Hodgkin lymphoma: results of the phase III MabCute study (596 Online Views)

Simon Rule, Wolney Gois Barreto, Javier Briones, Angelo M. Carella, Olivier Casasnovas, Chris Pocock, Clemens-Martin Wendtner, Francesco Zaja, Susan Robson, Lachlan MacGregor, Roger R. Tschopp, Sonja Nick, Martin Dreyling

https://doi.org/10.3324/haematol.2020.274803
Myeloid Biology

Unique ethnic features of DDX41 mutations in patients with idiopathic cytopenia of undetermined significance, myelodysplastic syndrome, or acute myeloid leukemia (1141 Online Views)

Eun-Ji Choi, Young-Uk Cho, Eun-Hye Hur, Seongsoo Jang, Nayoung Kim, Han-Seung Park, Jung-Hee Lee, Kyoo-Hyung Lee, Si-Hwan Kim, Sang-Hyun Hwang, Eul-Ju Seo, Chan-Jeoung Park, Je-Hwan Lee

https://doi.org/10.3324/haematol.2020.270553
Platelet Biology & its Disorders

Sequence-specific 2'-O-methoxyethyl antisense oligonucleotides activate human platelets through glycoprotein VI, triggering formation of platelet-leukocyte aggregates (1374 Online Views)

Martina H. Lundberg Slingsby, Prakrith Vijey, I-Ting Tsai, Harvey Roweth, Genevieve Couldwell, Adrian R. Wilkie, Hans Gaus, Jazana M. Goolsby, Ross Okazaki, Brooke E. Terkovich, John W. Semple, Jonathan N. Thon, Scott P. Henry, Padmakumar Narayanan, Joseph E. Italiano Jr.

https://doi.org/10.3324/haematol.2020.260059
Red Cell Biology & its Disorders

Sulfated non-anticoagulant heparin derivative modifies intracellular hemoglobin, inhibits cell sickling in vitro, and prolongs survival of sickle cell mice under hypoxia (654 Online Views)

Osheiza Abdulmalik, Noureldien H.E. Darwish, Vandhana Muralidharan-Chari, Maii Abu Taleb, Shaker A. Mousa

https://doi.org/10.3324/haematol.2020.272393

LETTERS TO THE EDITOR

SARS-CoV-2 infection in aplastic anemia (710 Online Views)

Daniele Avenoso, Judith C.W. Marsh, Victoria Potter, Antonio Pagliuca, Simon Slade, Fiona Dignan, Eleni Tholouli, Sajjan Mittal, Bernard Davis, Sudhir Tauro, Rachel Kesse-Adu, Morag Griffin, Elspeth Payne, Shreyans Gandhi, Austin G. Kulasekararaj

https://doi.org/10.3324/haematol.2021.279928

The insecticides permethrin and chlorpyrifos show limited genotoxicity and no leukemogenic potential in human and murine hematopoietic stem progenitor cells (236 Online Views)

Virginia C Rodriguez-Cortez, Maria Pilar Navarrete-Meneses, Oscar Molina, Talia Velasco-Hernandez, Jessica Gonzalez, Paola Romecin, Francisco Gutierrez-Aguera, Heleia Roca-Ho, Meritxell Vinyoles, Eric Kowarz, Pedro Marin, Sandra Rodriguez-Perales, Carlos Gomez-Marin, Patricia Perez-Vera, Felipe Cortes-Ledesma, Anna Bigas, Andrea Terron, Clara Bueno, Pablo Menendez

https://doi.org/10.3324/haematol.2021.279047

Somatic STAT3 mutations in CD8+ T cells of healthy blood donors carrying human T-cell leukemia virus type 2 (313 Online Views)

Daehong Kim, Mikko Myllymäki, Matti Kankainen, Timo Jarvinen, Giljun Park, Roberta Bruhn, Edward L. Murphy, Satu Mustjoki

https://doi.org/10.3324/haematol.2021.279140

Incidence and outcome of SARS-CoV-2 infection in patients with monoclonal gammopathy of undetermined significance: a case-control study (299 Online Views)

Nicola Sgherza, Paola Curci, Rita Rizzi, Vanda Strafella, Daniela Di Gennaro, Angelantonio Vitucci, Antonio Palma, Antonella Vita Russo Rossi, Francesco Albano, Pasquale Stefanizzi, Silvio Tafuri, Pellegrino Musto

https://doi.org/10.3324/haematol.2021.279895

Interferon α-induced SAMHD1 regulates human cultured megakaryocyte apoptosis and proplatelet formation (334 Online Views)

Seema Bhatlekar, Shancy Jacob, Emilia Tugolukova, Bhanu K. Manne, Yasuhiro Kosaka, Phillipe Loher, Ryan M. O’Connell, Vicente Planelles, Matthew T. Rondina, Isidore Rigoutsos, Paul F. Bray

https://doi.org/10.3324/haematol.2021.279864

Detection of ABL1 kinase domain mutations in therapy-naïve BCR-ABL1-positive acute lymphoblastic leukemia (273 Online Views)

Constance Baer, Manja Meggendorfer, Claudia Haferlach, Wolfgang Kern, Torsten Haferlach

https://doi.org/10.3324/haematol.2021.279807
Proactive vs Reactive Machine Learning in Health Care: Lessons From the COVID-19 Pandemic
Yuan Luo, PhD; Richard G. Wunderink, MD; Donald Lloyd-Jones, MD, ScM
Closing Evidence Gaps in Clinical Prevention: A Report From the National Academies of Sciences, Engineering, and Medicine
Tracy A. Lieu, MD, MPH; Alexis Wojtowicz, BA; Kathleen Stratton, PhD

Diagnosis and Management of Multiple Myeloma: A Review
Andrew J. Cowan, MD; Damian J. Green, MD; Mary Kwok, MD; et al.
Earn CME credit
Audio Clinical Review: Diagnosis and Management of Multiple Myeloma

Drug Approved to Prevent Graft-vs-Host Disease
Rebecca Voelker, MSJ
Association of Genetic Ancestry With the Molecular Subtypes and Prognosis of Childhood Acute Lymphoblastic Leukemia
Shawn H. R. Lee, MBBS; Federico Antillon-Klussmann, MD; Deqing Pei, MS; et al.

Editorial: Genetic Ancestry and Childhood Acute Lymphoblastic Leukemia Subtypes and Outcomes in the Genomic Era ; Karen R. Rabin, MD, PhD
The Blood Proteoform Atlas: A reference map of proteoforms in human hematopoietic cells

Rafael D. Melani, Vincent R. Gerbasi, Lissa C. Anderson, Jacek W. Sikora, Timothy K. Toby, Josiah E. Hutton, David S. Butcher, Fernanda Negrão, Henrique S. Seckler, Kristina Srzentić, Luca Fornelli, Jeannie M. Camarillo, Richard D. LeDuc, Anthony J. Cesnik, Emma Lundberg, Joseph B. Greer, Ryan T. Fellers, Matthew T. Robey, Caroline J. DeHart, Eleonora Forte, Christopher L. Hendrickson, Susan E. Abbatiello, Paul M. Thomas, Andy I. Kokaji, Josh Levitsky, Neil L. Kelleher
View

Hematopoietic tumors SLAM macrophages
Dan A. Erkes
View
 
EDITORIAL
 
The role of conferences in tackling inequalities 
 
 
COMMENT
 
Melflufen for multiple myeloma: a promise unfulfilled? 
Individualised doses of anti-thymocyte globulin and immune recovery after allogeneic HSCT 
Matchpoint: the game is not over for blast-phase chronic myeloid leukaemia 
Using immunogenetics to inform immunotherapy of lymphoid malignancies 
Thank you to our reviewers of 2021 
 
 
CORRECTIONS
 
Correction to Lancet Haematol 2021; 8: e410–21 
 

NEWS
 
2021 ASH annual meeting 
 

IN FOCUS
 
Reporting of trials with possible detrimental overall survival: a patient advocate perspective 
From residency training to professional life: which competencies and skills are most valued by haematologists in Brazil? 
Lakshmi Nayak: striving to contain the brain's deadliest killers 
 

ARTICLES
 
Melflufen or pomalidomide plus dexamethasone for patients with multiple myeloma refractory to lenalidomide (OCEAN): a randomised, head-to-head, open-label, phase 3 study 
Individualised dosing of anti-thymocyte globulin in paediatric unrelated allogeneic haematopoietic stem-cell transplantation (PARACHUTE): a single-arm, phase 2 clinical trial 
Ponatinib with fludarabine, cytarabine, idarubicin, and granulocyte colony-stimulating factor chemotherapy for patients with blast-phase chronic myeloid leukaemia (MATCHPOINT): a single-arm, multicentre, phase 1/2 trial 
KIR2DS1–HLA-C status as a predictive marker for benefit from rituximab: a post-hoc analysis of the RICOVER-60 and CLL8 trials 
 

REVIEW
 
Consensus guidelines and recommendations for infection prevention in multiple myeloma: a report from the International Myeloma Working Group 
 

VIEWPOINT
 
Risk stratified management approaches for smouldering multiple myeloma: clinical research becomes clinical practice 
 

CLINICAL PICTURE
 
Retinopathy associated with severe thrombocytopenia 

Malignancy-associated haemophagocytic lymphohistiocytosis 
Published online: January 28, 2022 
Audi Setiadi, Adi Zoref-Lorenz, Christina Y Lee, Michael B Jordan, Luke Y C Chen 
https://www.thelancet.com/journals/lanhae/article/PIIS2352-3026(21)00366-5/fulltext 

 

Betibeglogene Autotemcel Gene Therapy for Non–β0/β0 Genotype β-Thalassemia

F. Locatelli and Others

Efficacy and Safety of Gene Therapy for β‑Thalassemia

E. Payen

 

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La Fondazione GIMEMA – Franco Mandelli Onlus opera per promuovere la ricerca clinica indipendente sulle malattie ematologiche, diffondere cultura, divulgare il sapere scientifico e organizzare formazione.
GIMEMA informazione è la testata giornalistica che favorisce la divulgazione delle conoscenze scientifiche e delle attività della Fondazione tramite comunicazioni mirate sia a un pubblico generico che ai ricercatori. Si occupa inoltre della formazione professionale nell’ambito della ricerca clinica.

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