Explore the 10x Chromium System with the DNA Sequencing Core January 31!
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Director's Notes
A Message from Cassandra Wong
Happy New Year! 2017 is really starting with a bang. I'm sure many of you have seen by now the recent changes in security and information technology happening across campus, some of which we reiterate in below articles. Several of these updates impact the Biomedical Research Core Facilities in significant ways.

Earlier this month, Health Information & Technology Services announced changes to the policy on storing or sharing information. Moving forward, all devices storing sensitive information must be encrypted. When receiving any data files, samples or analysis from any Biomedical Research Core Facility, the information must be stored on an encrypted device.

There are several encrypted flash drives and devices available for purchase on M-Marketsite, including Apricorn Aeigis Padlock external hard drives with several TB capacity. Visit M-Marketsite for more information.

I hope 2017 is off to a great start for all of you.


Cassandra Wong, Director
Biomedical Research Core Facilities

Seminar on Single-Cell Genomic Analysis
Explore the Chromium System with the DNA Sequencing Core

Explore the exciting applications, services, and data support available on the 10x Genomics Chromium System:

Tuesday, January 31
4:00 PM
5:00 PM
Buhl 5915 (1241 Catherine St.)
Bob Lyons, Ph.D., Director, DNA Sequencing Core and
Chris Black, Sales Executive, 10x Genomics

The DNA Sequencing Core has recently acquired a new Chromium instrument, and is preparing to launch the single-cell RNAseq service.

A seminar flyer is available for download. For more information, visit the 10x instrument website.
Flow Cytometry Core Acquires New Bio-Rad ZE5
The Flow Cytometry Core is happy to announce the recent acquisition of the Bio-Rad ZE5 (Zed-EE Five) analyzer
This instrument was provided to the University of Michigan as part of an early access program giving us direct access to the development team and a voice in shaping the platform's future.
The instrument is equipped with four lasers (405/488/561/640nm) and 25 detectors, including a violet-based small particle detector. Analysis can be run via individual 5ml tubes, a 40-tube rack, or drawing directly from plates (up to 384 wells). The plate loader runs can be customized to standard or high-speed throughput depending upon the requirements of a given assay. The new instrument is currently located in the Cancer Center.
“Designed for ease of operation and producing FCS 3.0 files compatible with all major analysis packages, the ZE5 is ready to push your work to the next level,” Flow Cytometry Core Manager Dave Adams explained.
For more information, contact Dave via email.

Michigan Chemical Analysis Site Launches with $8.2 Million Award from NIH
Genomics. Systems biology. Epigenetics. Proteomics. Computation sciences. Metabolomics. Often these are thought of as separate disciplines, but a new funding initiative from the NIH is designed to see how all of these can work together to determine the molecular changes that occur during and after physical activity.

The initiative, called Molecular Transducers of Physical Activity Consortium (MoTrPAC), is launching several centers throughout the United States to study how these molecular changes that occur during and after exercise actually improve health and prevent disease in a new and holistic way.

One such center is being founded by two faculty members at the University of Michigan: Charles Burant, M.D., Ph.D., Professor of Internal Medicine and Professor of Molecular and Integrative Physiology, and Jun Li, Ph.D., Associate Professor of Human Genetics, Associate Professor of Computational Medicine and Bioinformatics, who have received a 6-year, $8.2 million grant to establish the Michigan Chemical Analysis Site (MiCAS) in the MoTrPAC Consortium.

Although researchers have demonstrated that physical activity is good for us in many ways, little is known about the molecules that cause these improvements. In most studies of physical activity and exercises, researchers focus on one condition or disease: diabetes, cancer, obesity, chronic pain, etc. Discovering the common bio-chemical underpinnings of these effects is critical to universal advancement of treatments.

The Consortium recognizes the need for a coordinated effort to assemble a comprehensive map of the proteins, peptides, circulating nucleic acids, lipids, hormones, and other molecules that change during or after exercise. These are the signals that are most likely to convey the effects of movement throughout the body.

The scope and breadth of the Consortium sets it apart from most collaborations, Dr. Li explained. Dr. Li will lead the data management and Bioinformatics Core for MiCAS.

What Will MiCAS Study?
The Consortium was created to assemble a comprehensive map of the proteins, peptides, circulating nucleic acids, lipids, hormones, and other molecules that change during acute exercise and following exercise training. These are the signals that are most likely to convey the effects of exercise throughout the body. The Consortium will study:
  • up to 3,000 individuals,
  • including analyzing their DNA and studying 25,000 blood samples,
  • 7,500 skeletal muscle biopsies,
  • and 7,500 fat biopsies.
Additional samples will be analyzed from animal models used to study the effects of exercise. For each sample, researchers will measure thousands of genes and metabolites.

“No single lab can progress or complete groundbreaking work alone on this scale,” Dr. Li said. “The scope and holistic approach of the Consortium is really what sets it apart from most collaborations. Michigan is excited and proud to be a part of it.”

As part of the Consortium, MiCAS will conduct metabolomics and lipidomics analysis of tissues collected from human participants and animals undergoing physical activity intervention. The research team will also provide support for integration of these data with the other ‘omics’ profiles and clinical data to create a better understanding of the molecular pathways that are important to the beneficial effects of physical activity.

MiCAS will draw researchers from multiple departments in the Medical School, including Human Genetics, Computational Medicine and Bioinformatics, Internal Medicine and Pathology as well as researchers from the School of Kinesiology. In addition, the Michigan Nutrition Obesity Research Center and the Michigan Regional Comprehensive Metabolomics Resource Core will provide infrastructure support for the project.

Dr. Burant, who will lead the Administrative and Analysis Cores, has been studying how exercise and activity affect health for most of his career. “Finally, this is a chance to really understand how the things that we as humans all do every day -- walking, running, going to the gym -- is good for both your health and how it makes you feel better,” he said. “We can evaluate specific exercises and daily activity levels to see how this all works, and perhaps optimize ideal levels of exercise. We may also find alternatives to exercise that have similar effects and improve overall health of people who can’t, or don’t, want to exercise.”

All of the information will be stored in a publicly accessible database that scientists can mine to address additional questions related to biological questions related to exercise. In addition, this trove of information can also be used to gain insight into other biological processes that are not part of the original study.

Ultimately, the research findings resulting from this program could help scientists and clinicians define optimal physical activity recommendations for people at various stages of life, as well as develop precisely targeted regimens for individuals with particular health needs.

The Molecular Transducers of Physical Activity in Humans’ effort to uncover the molecular changes that occur in response to movement is expected to transform clinical medicine’s use of physical activity as a treatment and preventive strategy.
Policy Update: Portable Device Security Update
Any Unencrypted Devices Storing Sensitive Information Must be Approved

A recent revision to UMHS Policy 01-04-502, Security of Portable Electronic Devices and Removable Media, will help Michigan Medicine better align with security requirements to protect our patient’s sensitive information.

Therefore, all devices that store sensitive information must be encrypted. This includes all removable media or portable electronic devices used to store, transfer, or access sensitive information.

Read the full announcement in Health System Headlines.

AirWatch/Wireless Access Update
Beginning April 27, the UMHS-8021X wireless network will no longer be available to non-core imaged mobile devices without AirWatch. Beginning in April, UMHS-8021X must be used to access UMHS resources, including shared drives, internal websites (intranets), etc. If you are on the M-Wireless network, you will have to connect to the VPN to access these types of services.

Users may continue to use the MWireless network to access the Internet, but Outlook email and other UMHS resources will be unavailable.

AirWatch Enrollment Support

  • You may self-enroll in AirWatch. Instructions are available on the AirWatch Enrollment page.
  • Contact the Service Desk at 734-936-8000, 24x7, for help over-the-phone.
  • Visit a Help Me Now location for in-person assistance.

We want to be sure that everyone is aware of the importance of safeguarding our data, our devices, and our network.
If you have questions, please contact the Service Desk by phone at (734) 936-8000 or via email:

Website Survey Gift Card Winner Announced
Congratulations to Research Investigator Rajat Banerjee from the School of Dentistry for winning the $50 gift card to Target for completing our BRCF website survey.

Thank you to everyone who took the time to complete the survey. We really appreciate the feedback we've received.
Ease the Task of Finding Research Funding: Resources and Techniques
Interested in being more organized and efficient about identifying research funding? This workshop will show you techniques for searching funding databases and setting up alerts.

Tuesday, February 14
1:00 PM – 2:00 PM
NCRC Building 10, G064

Note: Please bring your laptop for the hands-on portion of the class. Click here for registration information.
Traumatic Brain Injury Funding Opportunity
The Michigan Center for Integrative Research in Critical Care (MCIRCC) will host its third Grand Challenge, thanks to the Joyce and Don Massey Family Foundation. The Massey TBI Grand Challenge will fund integrated science teams that can develop and deliver innovative solutions to improve patient outcomes after severe traumatic brain injury (TBI).

Up to $600,000 is available to fund the development of diagnostic, device, therapeutic, or health IT solutions that address the initial ‘golden hours’ of care after severe TBI (generally the first 48 hours). Treatment administered during this critical timeframe can determine patient survival and have a significant effect on long-term function and disability.

Friday, February 17
8:30 AM – 5:00 PM
Location: North Campus Research Complex, Building 18 Dining Hall

To be considered for funding, you must attend the Grand Challenge event.

Click here to register!

If you have any questions, please contact
The Biomedical Research Core Facilities are part of the Office of Research, where our mission is to foster an environment of innovation and efficiency that serves the U-M Medical School community and supports biomedical science from insight to impact.
Copyright © 2017 Biomedical Research Core Facilities • University of Michigan Medical School Office of Research, All rights reserved.

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