CARIM Newsletter February 2016
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This newsletter contains information on the following subjects:
  • NHF Dr. E. Dekkers grants
  • NHS Studentbeurzen 2016
  • Mr Clean in NEJM 12 most notable articles
  • UM Best Master's Thesis Prize Milou Meeuse
  • Descartes-Huygens Prize Benoit Viollet
  • Toppublication Biochemistry
  • Who's new?!
  • Grant deadlines
  • Cardiovascular Grand Rounds Maastricht
  • Symposia & other lectures
  • Academic events
  • Media appearances

CARIM newsletter

Contributions for the newsletter (e.g. news of events and grants, important publications, societial impact related topics and research results related to CARIM's research) can be sent to Please submit the text in English and include a short title. The text should be max. 200 words. If applicable, include high resolution pictures and other documents.

NHF Dr E. Dekker Grants to CARIM

All 2015 NHS Dr E Dekker Senior Postdoc grants and the Established Investigator grant have been awarded to CARIM researchers.  The Dr E. Dekker programme of the Netherlands Heart Foundation (NHF) is a stimulation programme which contains fellowships for outstanding investigators – clinicians and non-clinicians – in the cardiovascular field. 

Earlier in 2015, Marc Strik and Martijn Brouwers received a Dr. E. Dekkers Arts voor aanvang Specialisatie and Junior Staflid grant of the NHS.

Click here for the full article on the CARIM website
Click here for the press release of the NHS
Click here for the video press release of the NHS

NHS Studentbeurzen 2016 - call for proposals

Binnen het Dr. E. Dekker-programma voor persoonsgebonden beurzen kent de Nederlandse Hartstichting negen beurzen. De Studentenbeurs is hier één van. Het doel van dit stipendium is om veelbelovende studenten te interesseren voor cardiovasculair onderzoek. De Nederlandse Hartstichting biedt deze studenten de mogelijkheid om buiten hun eigen universiteit een onderzoeksstage te volgen.

 Studenten vragen de beurs niet direct aan bij de Hartstichting. Elke universiteit heeft een contactpersoon waar de student informatie kan vragen en het aanvraagformulier kan opvragen. Binnen de Universiteit Maastricht is dit dhr. R. van der Zander. De contactpersoon neemt de aanvraag in behandeling en zorgt dat een selectiecommissie van de universiteit de beste studenten selecteert. Deadline indienen aanvraag is donderdag 18 februari 2016 bij het secretariaat CARIM, UNS 50

De voordracht bestaat uit een formulier met de volgende bijlagen:
  • Het aanvraagformulier van de Hartstichting
  • Een sollicitatiebrief van de student
  • Het curriculum vitae van de student
  • Een aanbevelingsbrief van de hoogleraar
  • Een planning van de stage
  • Een begroting van de stagekosten

Klik hier voor meer informatie.

MR CLEAN trial in NEJM 12 "most notable articles of 2015' 

De successvolle MR CLEAN trial is door de redactie van het New England Journal of Medicine uitgeroepen tot een van de 12 “most notable articles of 2015”. In de studie, die werd gesponsord door de Hartstichting is het gunstige effect van intra-arteriële behandeling voor het herseninfarct aangetoond.
Het artikel in de NEJM waarin de resultaten van de MR CLEAN trial beschreven wordt,  is volgens Google Scholar al  592 keer geciteerd, dat wil zeggen dat gemiddeld elke dag wel minstens 1 publicatie verscheen die naar deze landmark studie verwees. De trial werd geleid door neurologen en neuroradiologen uit het AMC, MUMC+ en Erasmus MC. Voor het MUMC+ waren Prof. dr. Robert van Oostenbrugge, neuroloog en Dr. Wim van Zwam, interventie-radioloog coördinator van het onderzoek.

Click here to download the collection.

UM master thesis prize for Milou Meeuse

During the Dies Natalis 2016, which took place on January 11, 2016, Milou Meeuse (intern at the Department of Molecular Genetics supervised by Willem Voncken and Dietbert Neumann, was presented a UM Best Master's Thesis Prize 2015.

Title: "MNK1a and AMPK: partners in metabolic adaptation?"

Click here for an overview of all the thesis prizes and other awards granted during the Dies Natalis. 

Descartes-Huygens Prize 2015 for Benoit Viollet

On the nomination of Dietbert Neumann, the Royal Netherlands Academy of Arts and Sciences (KNAW) has awarded the Descartes-Huygens Prize 2016 to molecular physiologist Benoit Viollet (Institute Cochin, Paris). He receives the prize for his excellent research on the energy sensor AMP-activated protein kinase (AMPK) and his contribution to the French-Dutch collaboration, with special reference to his previous successful collaboration with the cardiac metabolism group of Jan Glatz and Joost Luiken. The prize (€ 23,000) will enable Benoit Viollet to cover the cost for a 6-month research residence at Maastricht University. 

Recent top publication in Science Translational Medicine with researchers Biochemistry Dept. as co-authors

Kanin Wichapong, Gerry Nicolaes, Tilman Hackeng, Christian Weber, Hans Ippel and Dennis Suylen (Dept. of Biochemistry) are co-authors of the publication 'Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5' (Science Translational Medicine 2015 Dec 9;7(317)). IF: 15.8. 


In acute and chronic inflammation, neutrophils and platelets, both of which promote monocyte recruitment, are often activated simultaneously. We investigated how secretory products of neutrophils and platelets synergize to enhance the recruitment of monocytes. We found that neutrophil-borne human neutrophil peptide 1 (HNP1, α-defensin) and platelet-derived CCL5 form heteromers. These heteromers stimulate monocyte adhesion through CCR5 ligation. We further determined structural features of HNP1-CCL5 heteromers and designed a stable peptide that could disturb proinflammatory HNP1-CCL5 interactions. This peptide attenuated monocyte and macrophage recruitment in a mouse model of myocardial infarction. These results establish the in vivo relevance of heteromers formed between proteins released from neutrophils and platelets and show the potential of targeting heteromer formation to resolve acute or chronic inflammation.

Click here for the full article.
Who's new?!

My name is Chiara Campana, I’m from Poggio Torriana, Italy, and in January 2016 I started my PhD at the Department of Cardiology, Maastricht University under the supervision of Dr Jordi Heijman. My interest in biological mechanisms and life sciences began during my time at the University of Bologna, Italy, where I completed a bachelor’s and a master’s degree in Biomedical Engineering. This is also where I became interested in cardiac arrhythmias. During my PhD at Maastricht University I will be working on a project in computational cardiology that will focus on the use of multi-scale computational methods to study the electrophysiological mechanisms underlying  cardiac arrhythmias.
Grant deadlines


KNAW Programma Strategic Scientific Alliances - Deadline February 10, 2016
Click here for more information

EMBO Long-Term Fellowships - Deadline February 12, 2016
Click here for more information

NHS Studentbeursen 2016 - Internal deadline February 18, 2016
Click here for more information

NHS Dr. E. Dekker Junior Staflid - Deadline March 8, 2016
Click here for more information

NHS Dr. E. Dekker Senior Postdoc - Deadline March 8, 2016
Click here for more information

Goed Gebruik Geneesmiddelen Grote Trials Ronde 1 - Deadline 17 maart 2016 
Click here for more information (in Dutch)

CARIM Postdoctoral Talent Fellowship - Deadline April 18, 2016
Click here for more information

February 5 - Jurgen Bernhagen, MD, PhD, Medical University Munich, Germany
"MIF Function in Health and Cardiovascular Disease"

February 12 - Carnaval

February 19 - Max Nieuwdorp, MD, PhD, Amsterdam Medical Center

"Understanding Intestinal Microbiota in Cardiometabolism: Cause or Consequence"

February 26 - Marc Hoylaerts, PhD, University of Leuven, Belgium
"Models of Arterial and Venouw Thrombosis"

March 4 - Joanne van Ryn, PhD, Boehringer Ingelheim Pharma Biberach, Germany
"The Direct Thrombin Inhibitor, Dabigatran: Discovery, Development and Clinical Experience" 

March 11 - Henri Spronk, PhD, Maastricht University Medical Center
"Coagulation Proteases and Cardiovascular Disease"

Starts at 7.45 am, Academic hospital Maastricht, Meeting room A3-B3, level 3
Breakfast included! Registration not necessary

Click here for an overview of all the CGRM lectures of the first quarter of 2016

Symposia & events

8 Masterclasses “Molecular Anthropology”  by Prof. Mark Stoneking - Several dates in February and March 2015
Click here for more information

Puls 2016 - February 18, 2016
Click here for more information and the programme

Faces of Science (Marieke Rienks) in de OBA Amsterdam - 18 februari 2016

Click here for more information

Lecture Rafael Kramann - February 23, 2016
Click here for the invitation

Lectures Benjamin Meder and Christoph Dieterich - February 23, 2016
Click here for more information

Lecture Alan S. Maisel - March 1, 2016
Click here for more information

byteMAL Conference - March 9, 2016
Click here for more information

Scientific Workshop "Cardiovascular Research @ Bayer" - April 14-16. 2016
Click here for more information

Call for abstracts - 26th Genetics Retreat - April 21 until 22, 2016
Click here for more information. Abstract deadline: February 1, 2016

Call for abstracts - 50th Annual Scientific Meeting ESCI - April 27 - 29, Paris
Click here for more information. 


School Council meetings 2016:
- April 26, 12.00-14.00 hours
- June 27, 12.00-14.00 hours
- October 18, 12.00-14.00 hours

Academic events

PhD Conferral Annemieke Bouman, Thursday February 18, 2016, 14.00 hours
Supervisor: Prof. H. ten Cate
Co-supervisors: Dr A.J. ten Cate-Hoek, Dr M.A. Joore 
Title: "Post thrombotic syndrome, exploring aspects of pahtophysiology and personalized management"

PhD Conferral Martine Truijman, Friday February 19. 2016, 12.00 hours
Supervisors: Prof. W.H. Mess, Prof. J.E. Wildberger
Co-supervisor: Dr M.E. Kooi
Title: "Plaque vulnerability in stroke patients: a multimodality imaging approach"

PhD Conferral Marieke Rienks, Friday February 26, 2016, 12.00 hours
Supervisor: Prof. S. Heymans
Co-supervisor: Dr A.P. Papageorgiou
Titel: "Secreted Glycoproteins and Proteoglycans Orchestrate Inflammation in Cardiac Disease"


Media appearances

Tilman Hackeng & Stijn Agten (Dept. of Biochemistry) - C&EN, 18-01-2016: "Chilly accident leads to faster synthesis"

Casper Schalkwijk (Dept. of Internal Medicine) - Dagblad de Limburger/Limburgs Dagblad, 20-01-2016:  "De vitamine die suikeroplosser is''

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