CARIM Newsletter April 2017
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This newsletter contains information on the following subjects:
  • Tilman Hackeng Scientific Director
  • Prize FMS MR CLEAN
  • Paramount Papers
  • CARIM Postdoctoral Talent Fellowship
  • Grant deadlines
  • Cardiovascular Grand Rounds Maastricht
  • Symposia & other lectures
  • Academic events
  • Media moments

CARIM newsletter

Contributions for the newsletter (e.g. news of events and grants, important publications, societial impact related topics and research results related to CARIM's research) can be sent to Please submit the text in English and include a short title. The text should be max. 200 words. If applicable, include high resolution pictures and other documents.

As from December, two regular sections are added: "Paramount papers" and Translational trends". So, if you have a top publication or a translational development worth mentioning, please contact CARIM Office

Tilman Hackeng Scientific Director CARIM

As from April 1, 2017, Professor Tilman Hackeng successes Professor Thomas Unger as Scientific Director of CARIM for a term of six years. 

Tilman Hackeng studied chemistry (major biochemistry) at the University of Utrecht, The Netherlands. He obtained his Ph.D. with Prof. Bouma at the same University in 1993. Shortly after, he left for The Scripps Research Institute, La Jolla, CA, USA, where he worked in the laboratories of Profs. Griffin (Mol & Exp Medicine) and Kent (Chemistry). In 1998 he returned to the Netherlands as a Research Fellow of the Royal Netherlands Academy of Arts and Sciences (KNAW) at the Department of Biochemistry with Prof. Rosing at the Cardiovascular Research Institute of the University Maastricht (CARIM). Currently, he is head of the Department of Biochemistry and board member of CARIM. He is past president of the Netherlands Society on Thrombosis and Hemostasis (NVTH) and elected member of the Royal Holland Society of Sciences and Humanities (KHMW). He has published 141 papers with an h-index of 41 (WoS). 

Prof. Hugo ten Cate has taken over the leadership of Theme I as from April 1.

MR CLEAN wint prijs van Federatie Medisch Specialisten

Het gezamenlijke MR CLEAN-onderzoek van neurologen en radiologen naar intra-arteriële trombectomie van een acuut herseninfarct heeft de Wetenschaps- en Innovatieprijs van de Federatie Medisch Specialisten (FMS) gewonnen. De winnaars namen hun prijs in ontvangst tijdens het congres Medisch Specialist 2025.

Zij voerden een multidisciplinair onderzoek uit naar de effectiviteit van deze relatief nieuwe techniek, waarbij een afgesloten hersenbloedvat via katheterisatie wordt geopend. Dit is effectiever dan intraveneuze trombolyse, bij de patiënten die ervoor in aanmerking komen. De endovasculaire behandeling vindt steeds vaker plaats in Nederland. De jury vond de MR CLEAN-studie boven de andere inzendingen uitspringen vanwege het grensverleggende karakter ervan, de impact op de patiënt en vanwege de vak- en ziekenhuisoverstijgende samenwerking.

De Raad Wetenschap & Innovatie van de FMS nam het initiatief voor de Wetenschaps- en Innovatieprijs. Daarmee wil zij onderzoek, en samenwerking daarvoor, stimuleren, en de rol van de medisch specialist als onderzoeker belichten.

Wim van Zwam (Radiology) and Robert van Oostenbrugge (Neurology) zijn de coördinatoren vanuit Maastricht binnen MR CLEAN



Paramount papers

Integration of multiple large-scale “–omics” datasets yields mechanistic and etiological insights into genetic variation

Technological innovations, including micro-array and next generation sequencing platforms, enable the ascertainment of very large datasets describing individual genomes, transcriptomes, and epigenomes (among others).  To date, these “–omic” datasets, which allow for the hypothesis-free interrogation of many variants/molecules/etc., have been primarily analyzed individually.  The integration of multiple such datasets, however, provides an opportunity to assess their interplay and make novel mechanistic and etiological insights. 

To that end, the Biobank-based Integrating –Omics Study (BIOS), consisting of samples from across the Netherlands, was implemented.  Genomic, transcriptomic, and methylation data was assessed in approximately four thousand well-characterized individuals from six Dutch cohort studies.  CARIM researcher Aaron Isaacs and BIOS colleagues recently published back-to-back Nature Genetics papers describing results from this effort.  The first article demonstrates that approximately one-third of known disease- and trait-associated genetic variants, often intronic, have effects on methylation in trans and suggests that the biological mechanism underlying trans-methylation QTLs commonly involves a local effect on the expression of a nearby transcription factor that influences DNA methylation at the distal binding sites of that particular transcription factor.  The second describes the systematic identification of context-dependent expression QTLs using a hypothesis-free strategy, which will help to detect unanticipated intrinsic factors and external stimuli that modify the downstream effects of genetic risk factors.

These papers are available online at: and


MUMC+ study published in The Lancet questions hydration to prevent Contrast-Induced Nephropathy 

The interdisciplinary AMACING research group from the MUMC+ (Departments of Radiology & Nuclear Medicine, Cardiology, Internal Medicine, Clinical Epidemiology and Health Technology Assessment, and UM Department of Epidemiology) recently published their results in The Lancet.

Current national and international guidelines on the use of intravascular iodinated contrast material, such as is used in computed tomography or in coronary catheterizations and vascular interventions, recommend prophylactic hydration (intravenous hydration with normal saline for 4-12 hours before and after contrast) for all patients with an eGFR<45mL/min/1.73m2, and for all patients with an eGFR<60mL/min/1.73m2 in combination with diabetes or >1 risk factor (age, cardiovascular disease, nephrotoxic medication or anaemia). Implementation concerns an estimated 6-12 million high-risk patients each year, and imposes quite a burden on hospital logistics, health care budgets, and patient comfort. 

In the Netherlands these guidelines are imposed on hospitals quite strictly, and compliance is part of the annual quality assessment carried out by government instances. Yet, clinical- and cost-effectiveness of this prophylactic hydration treatment in protecting renal function has not been adequately studied in the population targeted by the guidelines to date. The aim of the AMACING trial [A MAastricht Contrast-Induced Nephropathy Guidelines trial] , was to fill this gap, by testing the implemented guidelines against a group receiving no prophylaxis. This has never been tested before.

Between June 17th, 2014 and July 17th, 2016 we prospectively included all adult patients referred for an elective procedure with intravascular iodinated contrast material and referred for prophylactic hydration. We excluded patients with eGFR below 30 mL/min/1.73m2, as well as dialysis, intensive care or emergency patients. We randomized these patients to either receive standard prophylactic hydration according to the guidelines or to receive no prophylaxis.

CIN incidence was 2.6% in the no prophylaxis group versus 2.7% in the standard prophylactic intravenous hydration group, 5.5% of iv hydrated patients suffered complications of the prophylactic intravenous hydration, and no instances of dialysis or related deaths were recorded within 35 days of contrast exposure. 

We found not giving prophylaxis to be non-inferior to giving the prophylaxis, as well as cost-saving. The latter amounts to a reduction in costs estimated at 50-100 million euro a year in the Netherlands alone. Our results imply that, assuming optimal contrast administration (pre-warmed, minimum dose, low osmolality, non-ionic, monomeric contrast), one might consider not giving prophylaxis to the patient group we studied without compromising patient safety. The results are an argument to revisit the current guidelines for the prevention of contrast induced nephropathy. 

The Lancet. Published Online: 20 February 2017. DOI:

CARIM Postdoctoral Talent Fellowship

Last year, CARIM has initiated a new fellowship to support talented PhD students in realizing an one-year research project as a Post-doc. It has a budget to provide one year of competitive salary as a Post-doc and must be spent partly at a foreign institute.  CARIM PhD students that are in the fourth year of their PhD trajectory are eligible.

The fellowship is intended to provide recently promoted, top CARIM talent a chance to gain experience abroad and return to CARIM to perform excellent research. It offers a competitive salary for a one year post-doctoral position.

This fellowship is designed to support talented PhD students in realizing an ambitious, innovative and international one-year research project as a Post-doc. As part of the grant you will be expected to go abroad for part of the post-doc in collaboration with high-impact collaborators, gather international experience and write prestigious grants such as the VENI.

The application deadline for the fellowship is April 17, 2017, after which a pre-selection will be made. The fellowship applications will be defended during the CARIM course week (Wednesday June 21, 2017).

Click here for more information and the application form.

Grant deadlines


Kootstra Talent Fellowship - Deadline April 1 (& October 1), 2017
Click here for more information

CARIM Postdoctoral Talent Fellowship - April 17, 2017
Click here for more information

LNVH - l'Oréal-UNESCO for women in science - Deadline May 8, 2017
Click here for more information

Click here to download the newly adjusted AXA Post Doctoral Fellowship application procedure 2016/2017

The calendar/overview of the prizes the FHML/UM would like to nominate candidates for is now avaible on:

April 7 - Prof. Alain Cribier, Rouen
"From Experimental Science to Routine Application in The Modern Cathlab"

Starts at 7.45 am, Academic hospital Maastricht, Meeting room A3-B3, level 3
Breakfast included! Registration not necessary

Click here for an overview of all the CGRM lectures of the first quarter of 2017

Symposia & events

Lorentz workshop Life Sciences with Industry 2017 Leiden: April 3-7, 2017
Click here for more information

Valorisation Day - April 11, 2017
Click here for more information

“Hack Your Future - innovate your education” - April 12, 2017
Click here for more information

MERLN Lecture Prof. Dimitrios Stamatialis - April 20, 2017
Click here for more information

IMCARIM seminar Prof. Ivo Fridolin - April 27, 2017
Click here for more information

3-day course ‘Klinische predictiemodellen - theorie en praktijk’, May 8-10, 2017
Click here for more information

Biomedica Life Sciences Summit - May 9-10, 2017
Click here for more information

CTCM Congress - May 11, 2017
Click here for more information

Lecture Dr Jan Weber - May 11, 2017
Click here for more information

51st Annual Scientific Meeting ESCI - May 17-19, 2017
Click here for more information

2nd joint meeting of the European Society for Microcirculation (ESM) and European Vascular Biology Organisation (EVBO), May 29-June 1, 2017
Click here for more information 

Workshop "Crafting the Valorisation Paragraph for you... by Knowledge Transfer Office @Maastricht University - June 2 & June 12, 2017
Click here for more information

PhD / Postdoc course Advanced Optical Microscopy - 12-16, June 2017
Click here for more information

Maastricht Microscopy Meeting (M3) on Advanced Optical Microscopy - June 16, 2017
Click here for more information 

8th International Conference on cGMP - June 23-25, 2017 (Bamberg/Germany)
Click here for more information

KNAW agenda April

CARIM School Council meetings 2017:
- April 25, 11.00-13.00h: UNS50 H1.319 (Paarse zaal)
- June 13, 13.30-15.30h: UNS50 H1.331 (Bonte zaal)
- October 9, 11.00-13.00h: t.b.d.

Academic events

PhD Conferral Rio Putra Juni, Wednesday April 19, 12.00 hours
Supervisor: Prof. L. de Windt
Co-supervisor: Dr P.A. da Costa Martins
Title: "microRNAs as regulators of cardiac vascular remodeling"

PhD Conferral Michael P.É. Clerx, Thursday April 20, 16.00 hours
Supervisors: Prof. R.L.M. Peeters; Prof. P.G.A. Volders
Co-supervisor: Dr P. Collins
Title: "Multi-scale Modeling and Variability in Cardiac Cellular Electrophysiology"

Media moments

De 'stille aandoening' als killer, 01-04-2017
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