CARIM Newsletter March 2017
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This newsletter contains information on the following subjects:
  • Hypertension Symposium March 24
  • CARIM Course Week 2017
  • Paramount Papers
  • Translational Trends
  • Grant deadlines
  • Cardiovascular Grand Rounds Maastricht
  • Symposia & other lectures
  • Academic events
  • Media moments

CARIM newsletter

Contributions for the newsletter (e.g. news of events and grants, important publications, societial impact related topics and research results related to CARIM's research) can be sent to Please submit the text in English and include a short title. The text should be max. 200 words. If applicable, include high resolution pictures and other documents.

As from December, two regular sections are added: "Paramount papers" and Translational trends". So, if you have a top publication or a translational development worth mentioning, please contact CARIM Office

Academy symposium "Focus on hypertension, the number one killer worldwide"

In the framework of the valedictory celebrations of Professor Thomas Unger, the symposium “Focus on hypertension, the number one killer worldwide” is organised on Friday March 24, 2017 in collaboration with the Royal Netherlands Academy of Arts and Sciences (KNAW).

Awareness and control of hypertension are among the greatest medical challenges of our time, with an enormous therapeutic potential.

This symposium will bring together European experts to address various aspects of hypertension research. It aims to further our understanding of the epidemiological importance of high blood pressure as the global number one cause of death, its underlying pathologies, hypertension-induced end-organ damage (with sudden events like stroke and chronic diseases such as heart and kidney failure), and modern therapeutic approaches based on antihypertensive drugs and non-pharmaceutical procedures such as baroreceptor stimulation or renal nerve ablation.

Date & time: 24 March 2017, 10.15 a.m. – 4.30 p.m.
Venue: La Bonbonnière, Achter de Comedie 1, 6211 GZ Maastricht
More information: Academy website and time table
Language: English



•    Rob Reneman, Professor Emeritus of Physiology, Maastricht University, on behalf of the Royal Netherlands Academy of Arts and Sciences and the Cardiovascular Research Institute Maastricht – Welcome and introduction
•    Christian Delles, Professor of Cardiovascular Prevention, University of Glasgow – Vascular biology and translational research in hypertension
•    Ana Briones, Associate Professor of Pharmacology, Universidad Autónoma de Madrid – Prostanoids and oxidative stress as mediators of alterations in vascular function, structure and mechanical properties in hypertension
•    Bram Kroon, Professor of Vascular Medicine, Maastricht University – Resistant Hypertension and device-based treatment
•    Gian Paolo Rossi, Professor of Internal Medicine and Chief of the Molecular Hypertension Lab, University Hospital Padova – Insights into the molecular mechanisms of endocrine hypertension
•    Maria-Christina Zennaro, Research Director, INSERM U970 Genetic mechanisms of aldosterone-related disorders, Paris – ENSAT-HT: Omics-based strategies for improved diagnosis and treatment of endocrine hypertension
•    Brian Harvey, Professor of Molecular Medicine, Royal College of Surgeons in Ireland, Dublin – Novel concepts of Aldosterone-MR and Protein Kinase D signalling in the kidney to regulate salt absorption
•    Round-up and discussion by Thomas Unger, Professor of Pharmacology and Experimental Medicine and Scientific Director of CARIM, Maastricht University

The symposium will conclude with Professor Thomas Unger’s valedictory lecture as Scientific Director of CARIM. Location: Maastricht University Aula, Minderbroedersberg 4-6.

The symposium will be hosted and moderated by Professor Rob Reneman, Professor Thomas Unger and Professor Harry Struijker Boudier, Maastricht University.

You are most welcome to attend the symposium. Participation is free, but registration is required. You can register by sending an e-mail to:

Announcement CARIM Courses - Registration will open on Monday March 20, 2017

As a CARIM PhD one is obliged to follow at least two CARIM courses of your choice during your PhD trajectory. Since last year the courses will alternate from year to year. This year you will be offered the possibility to choose between two cardiovascular courses developed and organized by our own CARIM researchers. The courses are:

•    Drug discovery and development
•    Vascular inflammation and thrombosis

Information for registration for the course  “Advanced microscopy and Vital Imaging”: If you would like to be sure of a place in this particular course next year, you can already indicate this now.

As part of the course week I’MCARIM organizes a social event on Monday evening and, on Wednesday afternoon your fellow PhD students will defend their application for the CARIM Fellowship Award.

Paramount papers

Cardiac resynchronisation therapy guided by electro-anatomic measurements and tissue substrate 

Cardiac resynchronization therapy (CRT) restores dyssynchronopathy in heart failure patients by simultaneous pacing of the ventricles (biventricular or BiV pacing). Despite the proven effectiveness of CRT, it is clear that benefit can be increased. One way to accomplish this is to ensure that the left ventricular (LV) pacing electrode is positioned at a site of late electrical activation and not in a scarred region.

The research group of Prof. Prinzen and Dr Vernooy from the department of Physiology and Cardiology tackled this problem by implementing a novel approach for LV pacing electrode placement by integration of electro-anatomic mapping measurements with delayed enhancement cardiac magnetic resonance imaging during the procedure of implanting the CRT device. The technical approach and initial experience in 18 patients has been recently published in Heart Rhythm. This paper will revolutionize cardiac pacing therapies in patients with heart failure.

This paper is online available at:

Translational Trends

NGR (CD13) targeting probe, one size fits all: evaluating angiogenesis in vivo

Noninvasive diagnostic and especially molecular imaging has encountered a rapid translational force in the last decade. Especially the introduction of multimodality imaging, and the availability of disease specific molecular imaging agents are important features. Molecular imaging techniques like positron emission tomography (PET) and single-photon emission computed tomography (SPECT) enable visualization of biological processes on the cellular and molecular level. This supports tailoring of individualized treatment concepts.

Angiogenesis is an endogenous healing process to restore tissue blood supply in response to ischemic injury such as myocardial infarction (MI). Angiogenesis can be further stimulated with pro-angiogenic therapy in ischemic heart disease. Noninvasive molecular imaging of angiogenesis enables both selection of patients who might benefit from pro-angiogenic therapy and evaluation of therapeutic responses.

As the CD13 receptor is selectively expressed in angiogenic blood vessels (in post-ischemia healing processes as well as in tumor angiogenesis), it can serve as a target for molecular imaging agents to visualize angiogenic processes in animal models and patients. CD13, or also called aminopeptidase N, selectively binds to peptides and proteins containing the amino acid sequence asparagine, glycine, and arginine (NGR). Based on this tripeptide sequence, a series of small peptides have been designed and synthesized at MUMC+ as molecular imaging agents for fluorescence microscopy, MRI and more recently for SPECT. Lately, the pharmacokinetic and pharmacodynamic profile of the first SPECT agent has been improved by using native chemical ligation (NCL) instead of disulfide bridging for cyclization of the peptide which led to a higher blood stability. In addition, a tetrameric version of this improved monomer has been designed and synthesized. This tetrameric NGR-based peptide showed a significantly higher specific uptake in infarcted myocardium compared to its monomeric counterpart and is a promising sensitive imaging agent for detection of angiogenesis in infarcted myocardium. The aim of the multidisciplinary team of the departments of biochemistry, radiology and nuclear medicine, and pathology has performed successful first in vivo experiments in animal models. Due to the potentially high impact in a clinical setting a translational concept to bring this new probe from bench to bedside is being developed.

Grant deadlines


Dr. E. Dekker Junior Staflid - March 7, 2017
Click here for more information

Dr. E. Dekker Senior Postdoc - March 7, 2017
Click here for more information

CVON Eerder herkennen - Deadline March 14, 2017
Click here for more information

Goed Gebruik Geneesmiddelen - Deadline March 21, 2017
Click here for more information

Kootstra Talent Fellowship - Deadline April 1 (& October 1), 2017
Click here for more information


March 10 - Kristiaan Wouters, PhD, Maastricht University Medical Center
"Innate immunity in cardiometabolic diseases: of mice and men"

March 17 - Marc Dweck, MD PhD, University of Edinburgh
"18F-fluoride imaging in cardiovascular disease"

March 24 - Prof. Perry Elliott, Institute for Cardiovascular Science, University College London
Title unknown

March 31 - Prof. Nico Pijls, TU Eindhoven/Catharina Hospital Eindhoven
" Measurent of Coronary Perfusion: FFR and Beyond"

April 7 - Prof. Alain Cribier, Rouen
"From Experimental Science to Routine Application in The Modern Cathlab"

Starts at 7.45 am, Academic hospital Maastricht, Meeting room A3-B3, level 3
Breakfast included! Registration not necessary

Click here for an overview of all the CGRM lectures of the first quarter of 2017

Symposia & events

21st European Vascular Course – March 5-7, 2017 
Click here for more information 

27th Genetics Retreat - March 16-17, 2017
Click here for more information

IMCARIM seminar Dr Timo Speer - March 16, 2017
Click here for more information

Scientific Workshop “Cardiovascular Research @ Bayer”, Germany, March 23 – 25, 2017
Click here for more information

Scientific meeting The Maastricht Study - March 30, 2017
Click here for more information

CARIM Lectures "Tissue engineering and regenerative medicine" - March 22, 2017
Click here for more information

Uppsala Kidney Oxygen Meeting 2017 - August 17-20, 2017, abstract Deadline: March 31
Click here for more information

Lorentz workshop Life Sciences with Industry 2017 Leiden: April 3-7, 2017
Click here for more information

3-day course ‘Klinische predictiemodellen - theorie en praktijk’, May 8-10, 2017
Click here for more information

CTCM Congress - May 11, 2017
Click here for more information

Workshop "Crafting the Valorisation Paragraph for you... by Knowledge Transfer Office @Maastricht University - June 2 & June 12, 2017
Click here for more information

PhD / Postdoc course Advanced Optical Microscopy - 12-16, June 2017
Click here for more information

3-day Systematic Reviewing Retreat - June 14-16, 2017
Click here for more information

2nd joint meeting of the European Society for Microcirculation (ESM) and European Vascular Biology Organisation (EVBO), May 29-June 1, 2017
Click here for more information 

Netherlands vascular biology meeting - November 2-3 2017
More information will follow

KNAW Agenda March 2017

CARIM School Council meetings 2017:
- April 25, 11.00-13.00h: UNS50 H1.319 (Paarse zaal)
- June 13, 13.30-15.30h: UNS50 H1.331 (Bonte zaal)
- October 9, 11.00-13.00h: t.b.d.

Academic events

PhD Conferral Remigius J.H. Martens, Thursday March 23, 24.00 hours
Supervisors: Prof. J. Kooman; Prof. C.D.A. Stehouwer
Co-supervisor: Dr R.M.A. Henry
Title: "Mildly reduced kidney function and albuminuria: looking beyound the kidney - the Maastricht Study"

Media moments

Mark Post (Dept. of Physiology) - Der Spiegel, 18-02-2017: "Der Fake-Burger"

INTRICARE (Th. Unger, T. Hackeng & L. Schurgers):  

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