CARIM Newsletter October 2016
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This newsletter contains information on the following subjects:
  • CARIM Day 2016
  • Van der Linden in Academy Honours Programme
  • Thomas Unger elected member ISH council
  • Puplication Circulation
  • Publication MR CLEAN
  • Report workshop Research Support Office
  • Who's new?!
  • Grant deadlines
  • Cardiovascular Grand Rounds Maastricht
  • Symposia & other lectures
  • Academic events

CARIM newsletter

Contributions for the newsletter (e.g. news of events and grants, important publications, societial impact related topics and research results related to CARIM's research) can be sent to Please submit the text in English and include a short title. The text should be max. 200 words. If applicable, include high resolution pictures and other documents.

SAVE THE DATE - CARIM DAG 2016, 2 november

CARIM DAY 2016 vindt plaats op woensdag 2 november

van dit jaar Robert Reneman lezing wordt gegeven door Professor Stephane Laurent

Na het succes van vorig jaar, de locatie van het symposium wordt opnieuw de Minderbroedersberg gevolgd door een feestelijke avond.
Meer informatie over het programma zal zo snel mogelijk worden verdeeld.

Noreen van der Linden in Academy Honours Programme for Young Artists and Scientists

Noreen van der Linden (Klinische Chemie) is door de KNAW geselcteerd voor het Academy Honours Program for Young Artists and Scientists. 

De Koninklijke Nederlandse Akademie van Wetenschappen (KNAW), de Akademie van Kunsten en De Jonge Akademie zijn in 2014 gestart met het programma arts/science: Academy Honours Programme for Young Artists and Scientists (voorheen Talent ontmoet talent), waarbij een groep van jonge kunstenaars en wetenschappers gedurende een jaar vier keer samenkomt in het Trippenhuis. Doel is kennismaken met elkaars wereld, ervaringen uitwisselen, mogelijke samenwerkingen onderzoeken en leden van de drie Akademies ontmoeten. De zienswijzen, invalshoeken en interesses van jonge kunstenaars en wetenschappers uit uiteenlopende disciplines zorgen voor bruisende en inspirerende debatten over thema’s die zowel voor de kunst als de wetenschap relevant zijn. De vorm en inhoud van de vier bijeenkomsten worden zoveel mogelijk door de groep zelf bepaald.

Thomas Unger elected member ISH council

Professor Thomas Unger, Scientific Director of CARIM, is elected as member of the ISH Council during the 26th Meeting of the International Society of Hypertension (ISH) that was held in Seoul, Korea, from 24 until 29 September. 

Established in 1966, the ISH is committed to promoting and encouraging the advancement of scientific research and knowledge and its application to the prevention and management of heart disease and stroke in hypertension and related cardiovascular diseases around the world.

Council members are responsible for furthering the aspirations and activities of the ISH, ensuring its efficient running and helping secure its continuity for the future. 

Publication accepted in Circulation with CARIM researchers as co-authors

Ben Sörensen, Alfons Houben, Tos Berendschot, Jan Schouten, Abraham Kroon, Carla van der Kallen, Ronald Henry, Annemarie Koster, Simone Sep, Pieter Dagnelie, Nicolaas Schaper, Miranda Schram, and Coen Stehouwer (Dept. of Internal Medicine1, Epidemiology, Social Medicine, or Opthalmology) are co-authors of the publication Prediabetes and Type 2 Diabetes are Associated with Generalized Microvascular Dysfunction: The Maastricht Study (Circulation 2016 – Will be soon be published ahead of print). IF: 17.047

Type 2 diabetes (T2DM) and prediabetes are associated with an increased risk of cardiovascular disease. This can be partly explained by macrovascular dysfunction, which already occurs in prediabetes (ticking clock hypothesis). Individuals with T2DM and prediabetes can also present with complications which are of microvascular origin. It is possible that microvascular, similar to macrovascular, dysfunction also may occur prior to the diagnosis of T2DM. Therefore, we investigated, in a population-based setting (The Maastricht Study), the associations of prediabetes, T2DM and measures of glycemia with microvascular function in both retina and skin. We demonstrated a decline in microvascular function in prediabetes with further deterioration in T2DM. In addition, inverse linear associations were found between measures of glycemia (HbA1c, fasting and 2h post load glucose levels) and microvascular function. Associations were independent of cardiovascular risk factors and diabetic microangiopathy. These data extend the ticking clock hypothesis to microvascular dysfunction in prediabetes, which may explain the increased risk of complications that are (in part) of microvascular origin, such as retinopathy and albuminuria, but also heart failure and cognitive decline. This suggests that both early hyperglycemia and microvascular dysfunction should be considered as potential targets of intervention for reducing the risk of microvascular complications in (pre)diabetes. 

Time to Treatment With Endovascular Thrombectomy and Outcomes From Ischemic Stroke: A Meta-analysis

The Highly Effective Reperfusion Evaluated in Multiple Endovascular Stroke Trials (HERMES) collaboration  pooled individual patient data from the 5 positive endovascular stroke trials, to investigate efficacy in subgroups too small to be conclusive in the individual trials. One of these trials was the Dutch MR CLEAN study of which Robert van Oostenbrugge (Neurology) and Wim van Zwam (Radiology)were co-PIs and both are involved in HERMES. In a recent study published in JAMA 2016; 316: 1279-1288, of which both were co-author, the HERMES collaboratorsestimated that for every 1000 patients achieving substantial endovascular reperfusion, 15 minutes faster emergency department door-to-reperfusion time would result in 39 patients having a less-disabled outcome at 3 months, including 25 additional patients achieving functional independence. An hour faster to reperfusion was estimated to benefit an additional 15.6% of patients successfully treated.

An editorial points to the meaning of these results for current acute stroke care. As known for decades: time is brain and this account also for endovascular treatment. Therefore, the results of this paper underscore the need for substantial system changes in acute stoke care to reach maximum benefit of endovascular treatment by reducing workflow. Also, it forces stroke neurologists to reshape the current pre-hospital emergency system in order to get eligable patients as soon as possible in a comprehensive stroke center.   As such, the editors of JAMA clearly stated the clinical and societal importance of this HERMES paper by referring to it by asking themselves: “Endovascular Thrombectomy for Ischemic Stroke. The Second Quantum Leap in Stroke Systems of Care?”

Report on September 2nd workshop, Research Support at Maastricht UMC+

“We’re going to submit our ideas to a large group of researchers and initiate pilot projects”
Innovative “Research Support” policy at Maastricht UMC+ slowly taking shape
An innovative policy meant to support research at Maastricht UMC+ is slowly taking shape. Several features of that policy became clear during a lively, inspiring Research Support workshop on September 2nd. The workshop also served to outline ideas for specific pilot projects. “We’re now going to submit our ideas to a large group of researchers. At the same time, we'll be initiating specific pilot projects with your cooperation,” said Bart Haex, project organization representative, at the end of the meeting.

Click here for the full report.


Who's New?!

Aomin Sun obtained her bachelor degree in 2009 in Northeast Forestry University (China). She then started to study developemental biology in Beijing Normal University and received her master in 2016. After her graduation, she was sponsored by the Chinese Scholarship Council and became a PhD student in the Department of Molecular Genetics in September 2016 under supervision of Prof. Jan Glatz, Dr Dietbert Neumann and Dr Joost Luiken. Her PhD project aims to unravel signaling downstream of protein kinase-D1 in the regulation of cardiac substrate preference and apply it to restore cardiac function in diabetic cardiomyopathy.

My name is Kim van Kuijk and after finishing my master Biomedical Sciences at Maastricht University, immediately a new challenge appeared for me: a PhD at the Pathology department. During my PhD I'm going to focus on atherosclerosis and oxygen-sensing. The title of my research plan will be: Chaperone-mediated autophagy (CMA): linking oxygen sensing to cholesterol and atherosclerosis.

Ilona Cuijpers obtained her Bachelor and Master degrees in Biomedical Science from the Faculty of Health, Medicine and Life Sciences, Maastricht University, in 2014 and 2016, respectively. During her Bachelor and Master internships, she studied the underlying pathology of non-alcoholic steatohepatitis (Dr Wouters, Internal Medicine, Maastricht University) and Niemann-Pick type C1 disease (Prof. Dr. Shiri-Sverdlov, Molecular Genetics, Maastricht University). Her interest in inflammatory responses and cardiovascular diseases brought her to join the group of Dr. Anna Papageorgiou and Prof. Stephane Heymans. In September 2016, she started to work as a PhD student at the Cardiology Department, Maastricht University with the aim of further unraveling the mechanism(s) underlying the development of Heart Failure with preserved Ejection Fraction (HFpEF), firstly in a new experimental model and secondly translating these finding to HFpEF patients. Specifically, the role of extracellular matrix proteins in regulating microvascular changes and inflammation during HFpEF progression will be investigated.

Indira Vonhögen moved from Curaçao to Maastricht, where she attained her bachelor in Molecular Life Sciences (2009-2012) followed by the “A-KO” (Physician-Clinical researcher) master programme (2012-2016). She is currently working on the Queen of Hearts project which is led by Dr Ghossein. This project is a collaboration between the dept of Obstetrics and Gynaecology and the experimental Cardiology. The main aim of Indira’s project will be bringing the molecular research lines from the department of experimental Cardiology under supervision of Prof. Leon de Windt closer to clinical practice. She will dedicate her research project towards the search for circulating biomarkers for the detection of subclinical heart failure, and concentric remodelling as characteristic of woman with a history of pre-eclampsia; as well as genome wide association studies within this cohort.

My name is Ilvy Geraets. I am 24 years old and born in Schinveld, the Netherlands. I studied Biomedical Sciences at Maastricht University, with a specialization in Cardiovascular Biology and Medicine. For my graduation internship, I visited the Department of Cardiovascular and Renal Research at the University of Southern Denmark, Odense. Here I focused on the influence of small local fat depots on heart and blood vessels. In September 2016, I started my PhD at the Department of Genetics and Cell Biology under the supervision of Prof. Jan Glatz, Dr Miranda Nabben and Dr Joost Luiken. My main research interest is on metabolic phenotyping of the heart during the development of heart failure.


Grant deadlines


Innovational Research Incentives Scheme Vidi - Deadline October 6, 2016
Click here for more information

PhD projecten (imaging) ikv samenwerking tussen Universiteit Luik en Universiteit Maastricht - Deadline October 10, 2016
Click here for more information

ERC Starting Grant - Deadline October 18, 2016, 17.00 hours
Click here for more information

NWO Rubicon - Deadline December 1, 2016
Click here for more information

The Gates Cambridge Scholarship - Deadline December 7, 2016
Click here for more information

October 7 - Gudrun Antoons, PhD, Maastricht University Medical Center+
"Stretching the heart: molecular mechanisms and relevance for arrhythmias"

October 14 - Reza Wakili, MD, University Hospital Munich, Germany
"Molecular Mechanisms of AF - Translation into Clinical Practice and Vice Versa

October 21 - Oliver Grottke, MD, PhD, University Hospital RWTH Aachen, Germany
"Scientific evidence of the reversal of direct oral anticoagulants"

November 4 - John Eikelboom, MD, PhD, McMaster University, Hamilton, Canada
"NOAC anti NOAC"

November 11 - Marco Das, PhD, Maastricht University Medical Center+
"Individualized cardiovascular imaging"

November 18 - Jens Cosedis Nielsen, MD, DMSc, PhD, Aarhus University, Denmark
"Results of the DANISH trail. Primary prophylactic ICD for patients with non-ischemic heart failure"

Starts at 7.45 am, Academic hospital Maastricht, Meeting room A3-B3, level 3
Breakfast included! Registration not necessary

Click here for an overview of all the CGRM lectures of the last quarter of 2016

Symposia & events

Netherlands Vascular Biology Meeting -  October 5 & 6, 2016
Click here for more information. Abstract deadline: September 5 12.00 hours

tUL Research Day - October 5, 2016
Click here for more information

Biomarker Summit Europe - October 5-7, 2016 Berlin, Germany
Click here for more information

Pélerin Science Symposium - October 5, 2016
Click here for more information

4th National eScience Symposium - October 13, 2016
Click here for more information

20th Annual Meeting of the European Council for Cardiovascular Research (ECCR) - October 14-16, 2016
Click here for more information. Abstract deadline: July 11, 2016

PhD course 'Systematic Reviewing and Critical Appraisal' - October 18, 2016
Click here for more information - Registration deadline: September 1, 2016

IMCARIM seminar Dr Nicola Wilck - October 27, 2016
Click here for more information

Dutch Physiology Days 2016 Maastricht - November 25-26, 2016
Click here for more information

Agenda KNAW October

School Council meetings 2016:

- October 18, 12.00-14.00 hours


Academic events

PhD Conferral Stefan Geijselaers, Wednesday October 5, 10.00 hours
Supervisors: Prof. C.D.A. Stehouwer, Prof. G.J. Biessels (UU)
Co-supervisor: Dr S.J.S. Sep
Title: "Cognitive Dysfunction: At the crossroads of glucose metabolism and vascular function"

PhD Conferral Marie-Claire Kleinegris, Wednesday October 12, 12.00 hours
Supervisor: Prof. H. ten Cate
Co-supervisors: Dr A.J. ten Cate-Hoek, Dr G.H. Koek, Dr B. de Laat
Title: "Coagulation testing in atherosclerosis and liver disaese"

PhD Conferral Anna Daamen, Wednesday October 12, 16.00 hours
Supervisors: Prof. J.M.G.A. Schols, Prof. J.P.H. Hamers, Prof. HP. Brunner-La Rocca
Title: "Heart failure in nursing home residents; Prevalence, Diagnosis and Treatment"

PhD Conferral Elien Engels, Wednesday October 19, 14.00 hours
Supervisor: Prof. F.W. Prinzen
Co-supervisor: Dr K. Vernooy
Title: "Something old, something new: vectorcardiographic loop size and response to cardiac resynchronization therapy"

PhD Conferral Bart Spronck, Wednesday October 19, 16.00 hours
Supervisor: Prof. T. Delhaas
Co-supervisors: Dr K.D. Reesink, Dr R.T.A. Megens (Munich)
Title: "Stiff vessels approached in a flexible way: Advancing quantification and interpretation of arterial stiffness"

PhD Conferral Xiaoqing Zhu, Thursday October 20, 12.00 hours
Supervisor: Prof. J.F.C. Glatz
Co-supervisor: Dr D. Neumann, Dr J.W. Voncken
Title: "The AMPK-MNK1 signaling axis"

PhD Conferral Sophie Deckx, Friday October 21, 14.00 hours
Supervisor: Prof. S. Heymans
Co-supervisor: Dr A. Papageorgiou
Title: "Matrix Glycoproteins and Proteoglycans are Paramount in cardiac disease"

PhD Conferral Tom Mastenbroek, Thursday Octoner 27, 10.00 hours
Supervisor: Prof. J.W.M. Heemskerk
Co-supervisor: Dr J.M.E.M. Cosemans
Title: "Role of platelets in vascular remodeling: acute and persistent effects"
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