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CARIM Newsletter February 2017
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This newsletter contains information on the following subjects:
  • New controller CARIM
  • Inauguration Bram Kroon
  • Paramount Papers
  • Translational Trends
  • Who's new?!
  • Grant deadlines
  • Cardiovascular Grand Rounds Maastricht
  • Symposia & other lectures
  • Academic events
  • Media moments

CARIM newsletter


Contributions for the newsletter (e.g. news of events and grants, important publications, societial impact related topics and research results related to CARIM's research) can be sent to carim-office@maastrichtuniversity.nl. Please submit the text in English and include a short title. The text should be max. 200 words. If applicable, include high resolution pictures and other documents.

As from December, two regular sections are added: "Paramount papers" and Translational trends". So, if you have a top publication or a translational development worth mentioning, please contact CARIM Office

New controller CARIM

My name is Lynn Lemeer, 32 years old and currently living in Stein. As of February 1st, I started as controller for CARIM. After completing my master in International Business at Maastricht University, I have had several diverse positions in controlling. The last couple of years I have worked as corporate financial controller for Q-Park. In my spare time I like to ride my horses, go for dinner and I love to travel.

I am very excited to be back at Maastricht University, and I look forward to working with you. 

Lynn Lemeer will success Sietske Satijn as from February 2017.

 

Inaugural lecture prof.dr. Bram Kroon,


On January 13, 2017, Bram Kroon was appointed extraordinary professor ‘Vasculaire geneeskunde i.h.b. vasculaire gevolgen bij Hypertensie’ and held his inaugural lecture 'Niet alleen met medicatie’. Bram Kroon is vascular internist at the MUMC+ and Principal Investigator at CARIM.

Click here for the press release regarding his appointment (only in Dutch)

Paramount papers

Prediabetes and type 2 diabetes are associated with generalized microvascular dysfunction: The Maastricht Study 

The research group of Coen Stehouwer from CARIM’s Department of Internal Medicine recently published a paper in the high impact journal ‘Circulation’. 

Type 2 diabetes (T2DM) and prediabetes are associated with an increased risk of cardiovascular disease. This can be partly explained by macrovascular dysfunction, which already occurs in prediabetes (ticking clock hypothesis). Individuals with T2DM and prediabetes can also present with complications which are of microvascular origin. It is possible that microvascular, similar to macrovascular, dysfunction also may occur prior to the diagnosis of T2DM. 

Therefore, we investigated, in a population-based setting, the associations of prediabetes, T2DM and measures of glycemia with microvascular function in both retina and skin. We demonstrated a decline in microvascular function in prediabetes with further deterioration in T2DM. In addition, inverse linear associations were found between measures of glycemia (HbA1c, fasting and 2h post load glucose levels) and microvascular function. Associations were independent of cardiovascular risk factors and diabetic microangiopathy. 
These data extend the ticking clock hypothesis to microvascular dysfunction in prediabetes, which may explain the increased risk of complications that are (in part) of microvascular origin, such as retinopathy and albuminuria, but also heart failure and cognitive decline. This suggests that both early hyperglycemia and microvascular dysfunction should be considered as potential targets of intervention for reducing the risk of microvascular complications in (pre)diabetes. 

This paper is online available at: http://circ.ahajournals.org/content/134/18/1339 


Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure

Heart failure (HF) remains a common cause of death and disability and is associated with altered signal transduction via -adrenoceptors and G proteins, resulting in reduced adenylyl cyclase-mediated cAMP formation and contributing to contractile dysfunction. Nucleoside diphosphate kinases (NDPKs) can modulate G-protein activity and are enriched at the plasma membrane of end-stage HF patients. However, their relevance for HF pathophysiology is largely unknown, particularly for the NDPK C isoform.

Together with collaborators from various centers in Germany, Jordi Heijman (Dept. of Cardiology, CARIM) recently published a study in Circulation, showing for the first time a potential critical role for NDPK-C in the suppression of cAMP formation in HF patients. In particular, this study identified that NDPK-C is crucial for the interaction between NDPKs and G proteins, building complexes and scaffolding them at the plasma membrane. These interactions regulate cAMP levels and cardiomyocyte contractility. In HF patients, NDPK-C switched from predominantly Gs stimulation to activation of Gi. These findings provide a potential mechanism for the detrimental decrease in cAMP and related dysfunction previously described in HF patients and position NDPK C as a novel critical determinant of AR/cAMP signaling that contributes to impaired cardiac function and remodeling in human HF.



Reference: Abu-Taha IH*, Heijman J*, Hippe HJ, Wolf NM, El-Armouche A, Nikolaev VO, Schäfer M, Würtz CM, Neef S, Voigt N, Baczkó I, Varró A, Müller M, Meder B, Katus HA, Spiger K, Vettel C, Lehmann LH, Backs J, Skolnik EY, Lutz S, Dobrev D#, Wieland T# (2017) Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure. Circulation, Published online on Dec 7, 2016. *equally contributing first authors, #co-senior and co-corresponding authors

Translational Trends

How stroke begets AF’


Atrial fibrillation (AF) affects over 300.000 people in The Netherlands and over 6 million in Europe. AF is progressive over time causing debilitating symptoms, stroke, heart failure and premature mortality. A logical pathogenic signalling molecule between these deleterious events is thrombin causing hypercoagulability, vascular remodelling through endothelial activation, eventually leading to atherothrombosis, atrial wall fibrosis and AF progression. Based on initial translational research (http://eurheartj.oxfordjournals.org/content/early/2016/04/11/eurheartj.ehw119.references-only) a national translational research project RACE-V supported by the Netherlands Heart Foundation has been initiated recently by HVC and CARIM departments biochemistry, physiology, internal medicine, and cardiology, in collaboration with UMCG and LUMC (CVON2014-09, RACE V Reappraisal of Atrial Fibrillation: Interaction between hyperCoagulability, Electrical remodelling, and Vascular Destabilisation in the Progression of AF).

The central hypothesis of RACE-V links thrombin activation and hypercoagulability to AF progression and vice versa. Therefore the project focuses on how AF affects blood coagulation and vascular function and vice versa, how thrombin generation enhances vascular changes, atrial wall remodelling and AF progression. Since early stage AF occurs in attacks, the effect of AF on thrombin formation is studied using a novel approach in which consenting patients are implanted with an injectable miniature subcutaneous rhythm device, monitoring their heart rhythm continuously. Once AF occurs patients are called to the hospital and CARIM lab to perform extensive phenotyping of atrial and genetic as well as coagulation biomarkers, in- and outside the AF episodes.

RACE-V will address the relation of hypercoagulability to other well established factors mediating AF progression and thereby contribute to our understanding why AF and stroke are associated with each other. This will not only reduce disease burden but also lead to new pharmacological and genetic therapies to prevent AF progression and stroke in patients suffering from AF (www.race-v.org).  

Who's new?!

My name is Billy Scaf, and I am 26 years old. I studied Animal Sciences at Wageningen university, where I graduated in 2014 at the Human and Animal Physiology department. I fulfilled my master thesis here in Maastricht at the Biochemistry department, and after that I have worked as analyst and study assistant at the Toxicology department of Charles River Laboratories in 's-Hertogenbosch.  Since the beginning of this year I am a PhD student at the Physiology department. I am joining the group of Prof. Uli Schotten, but will also be involved with the group Prof. Hugo ten Cate of the Biochemistry department. The focus of my project will be on mechanisms by which hypercoagulability promotes structural remodeling and progression of atrial fibrillation.


I am Shijie Ding, a 27 year-old Ph.D. student from Nanjing Agricultural University, China. I have done quite a lot of work on isolation and cultivation of porcine muscle stem cells. I will work on 3D culture of myoblast cells with edible hydrophilic gels at the Department of Physiology under the supervision of Prof. Mark Post.









My name is Alexandra Heinzmann, and I obtained my Bachelor’s degree at Zuyd University of applied sciences in Heerlen in 2008. After my graduation, I started working as a research technician at the Biochemistry Department of this university for almost 6 years. This work inspired me to continue my Master studies in Maastricht and I graduated in 2016. Happy to be back in the Biochemistry family, I started my PhD in January, in the group of Dr Rory Koenen. My project is focussing on intercellular communication and immunomodulatory activities of platelet extracellular vesicles in vascular inflammation.

Grant deadlines

DOWNLOAD HERE THE SUBSIDY CALENDAR FOR 2017

ERC Consolidator grant - Deadline February 9, 2017
Click here for more information

Diabetes Fonds Fellowships - February 13, 2017
Click here for more information

Mini-symposium on models and pathway diagrams - February 16, 2017
Click here for more information

Dr. E. Dekker Junior Staflid - March 7, 2017
Click here for more information

Dr. E. Dekker Senior Postdoc - March 7, 2017
Click here for more information


CVON Eerder herkennen - Deadline March 14, 2017
Click here for more information

Goed Gebruik Geneesmiddelen - Deadline March 21, 2017
Click here for more information

 


February 10 - Gérard Giraudon, MD, PhD,  directeur du centre de recherche Inria Sophia Antipolis Quebec Canada
"Left Atrial Isolation"


February 24 - Andy Baker, MD, PhD, University of Edinburgh, Scotland
"Implementing molecular therapies that target cardiovascular injury and repair"


March 3 - Carnaval, no lecture

March 10 - Kristiaan Wouters, PhD, Maastricht University Medical Center
"Innate immunity in cardiometabolic diseases: of mice and men"


Starts at 7.45 am, Academic hospital Maastricht, Meeting room A3-B3, level 3
Breakfast included! Registration not necessary


Click here for an overview of all the CGRM lectures of the last quarter of 2016

Symposia & events

Maastricht AF - Crossing Borders - February 8-10, 2017
Click here for more information

Seminar Prof. Carlijn Bouten - February 9, 2017
Click here for more information


Lecture Dr. P. Eline Slagboom - February 15, 2017
Click here for more information


Maastricht Consensus Conference on Thrombosis (MCCT) - February 22-24, 2017
Click here for more information

21st European Vascular Course – March 5-7, 2017 
Click here for more information 


27th Genetics Retreat - March 16-17, 2017
Click here for more information

Scientific Workshop “Cardiovascular Research @ Bayer”, Germany, March 23 – 25, 2017
Click here for more information

3-day course ‘Klinische predictiemodellen - theorie en praktijk’, May 8-10, 2017
Click here for more information

PhD / Postdoc course Advanced Optical Microscopy - 12-16, June 2017
Click here for more information

3-day Systematic Reviewing Retreat - June 14-16, 2017
Click here for more information


Revolution in Biomedicine summer programme Imperial College London - July 3-28, 2017
Click here for more information

2nd joint meeting of the European Society for Microcirculation (ESM) and European Vascular Biology Organisation (EVBO), May 29-June 1, 2017
Click here for more information 

Netherlands vascular biology meeting - November 2-3 2017
More information will follow

Agenda KNAW February 2017

CARIM School Council meetings 2017:
- April 25, 11.00-13.00h: UNS50 H1.319 (Paarse zaal)
- June 13, 13.30-15.30h: UNS50 H1.331 (Bonte zaal)
- October 9, 11.00-13.00h: t.b.d.

Academic events

41 Dies Natalis - Tuesday February 7

PhD Conferral Dionne Maessen, Friday February 17, 14.00 hours

Supervisors: Prof. C.G. Schalkwijk; Prof. C.D.A. Stehouwer
Co-supervisor: Dr N.M.J. Hanssen
Title: "Alpha-dicarbonyl stress: implications for obesity and type 2 diabetes?"

PhD Conferral Jan Guy Bogaarts, Thursday February 23, 10.00
Supervisor: Prof. W.M. Mess
Co-supervisors: Dr.Ir. J.P.H. Reulen; Dr.ir. E.D. Gommer
Title: "Quantitative EEG and machine learning methods for the detection of epileptic seizures and cerebral asymmetry"

Media moments

Aalt Bast (Dept. of Pharmacology & Toxicology) - De Volkskracht, 21-01-2017: "Over de invloed van voeding op onze gezondheid. Deze week: is vlees alleen maar ongezond?"
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