CARIM Newsletter November 2015
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This newsletter contains information on the following subjects:
  • Announcement CARIM MF
  • Talk Paul Volders
  • Publication Cardiology
  • YIA Monika Rech
  • Who's new?!
  • Grant deadlines
  • Cardiovascular Grand Rounds Maastricht
  • Symposia & other lectures
  • Academic events
  • Media appearances

CARIM newsletter

Contributions for the newsletter (e.g. news of events and grants, important publications, societial impact related topics and research results related to CARIM's research) can be sent to Please submit the text in English and include a short title. The text should be max. 200 words. If applicable, include high resolution pictures and other documents.

Announcement CARIM Muroidian Facilty 

Previously, the CARIM Muroidian Facility was introduced as a dedicated core facility providing technical support and expertise for small animal experiments (more information at The facility is now financially supported by the Faculty of Health Medicine and Life Sciences, allowing us to offer our expertise at significantly reduced costs. For more information, please contact us at

DUTCH: In gesprek met Paul Volders: Hoe kunnen we hart- en vaatziekten op individueel niveau vroeg voorspellen en op individueel niveau voorkomen en behandelen?

Iedere twee weken gaan experts van het Maastricht UMC+ in op één van de vragen die zijn gesteld in het kader van de Nationale Wetenschapsagenda. Deze keer bespreken cardiologen prof. dr. Paul Volders en drs. Rachel ter Bekke de volgende vraag:

Hoe kunnen we hart- en vaatziekten op individueel niveau vroeg voorspellen en op individueel niveau voorkomen en behandelen?

Klik hier voor het hele artikel.

Promising results from the Department of Cardiology

The clinical research group of Prof. Stephane Heymans has recently published a landmark paper regarding dilated cardiomyopathy (DCM) patients in the Journal of the American College of Cardiology. 
DCM is a serious heart condition, as reflected by the number one cause of heart transplantation in young adults. It is characterized by decreased cardiac function and dilatation of the ventricle in the absence of common causes such as myocardial infarction or valvular disease. The researchers evaluated 213 DCM patients using both heart tissue biopsies and genetic screening in addition to the standard diagnostic methods. By applying this combined approach, patients can be classified based on individual characteristics. Using this method, a cause for DCM can be found in 75% of patients such as genetic mutation, virus infection, toxic exposure etc. Although a genetic predisposition plays an important role, more is needed to develop DCM as not all patients with a genetic mutation will progress towards DCM. Interestingly, it appeared that the combination of triggers, i.e. a genetic mutation and a virus infection, was associated with a poor outcome. These results will lead to new insights regarding treatment and perhaps more importantly, prevention of DCM. 

Young Investigator Award to Monika Rech

Monika Rech (Department of Cardiology) won the Bill Stanley young investigator award at the 13th annual meeting of the Society for heart and Vascular metabolism in New York. 
Who's new?!

Recently, I have started as a PhD student at CARIM School for 
Cardiovascular Diseases and, as a new member, I would like to introduce myself. My name is Nynke Simons and I finished the A-KO master at Maastricht University almost two months ago. After my final research internship at the Department of Internal Medicine, I have been given the opportunity to continue my research as a PhD student (mentors: Dr M.C.G.J. Brouwers, Prof. N.C. Schaper, Prof. C.D.A. Stehouwer). In the upcoming years, I will study the cardiometabolic consequences of non-alcoholic fatty liver disease, a subject I have been interested in for many years. I am excited and looking forward to the next four years. 

My name is Sjeng Quicken and I recently finished my studies of medical engineering at the Eindhoven University of Technology. The coming years I will perform a PhD at the Department of Biomedical Engineering. During my PhD I will research the hemodynamics and mechanics of a type of arteriovenous graft for hemodialysis patients that is currently
under development. Together with the research efforts of other groups and researchers this will hopefully result in a graft that does not suffer from the complications that are typical for grafts that are currently used.

My name is Sytze Rensma. In August of this year, I graduated from 
 medical school, and this October, I started as a PhD student in the Maastricht Study. I am interested in (patho)physiology, and thus am really looking forward to the upcoming years. Before starting here, I worked as a student-assistant in the Department of Immunology, and during my final year in medical school, I followed a research participation internship in CARIM . Besides research, I enjoy (outdoor) sports and playing guitar. I hope to learn a lot during my PhD trajectory, and to meet and work with a lot of you in the future.

My name is Tan Lai Zhou and recently started as a PhD-student within The Maastricht Study. I studied Medicine in Maastricht and after finishing my Master’s, I could immediately start with the research I have been appointed to, namely the association between blood pressure variability, arterial stiffness and glucose metabolism status. The aim is to clarify these associations, in the hope to improve knowledge about the progression of complications within individuals with type 2 diabetes. I’m very excited to work hard in this project and hope to learn much from my colleagues!

Grant deadlines


ERC Starting Grant - Deadline November 17, 2015
Click here for more information

Dr Dekker Junior Postdoc - Deadline January 19, 2016
Click here for more information

Dr Dekker Arts in opleiding tot specialist - Deadline January 19, 2016
Click here for more information

ERC Consolidator Grant  - Deadline February 2, 2016
Click here for more information

EMBO Long-Term Fellowships - Deadline February 12, 2016
Click here for more information

November 13 - Philipp Wild, MD, PhD, Johannes Gutenberg University Mainz, Germany
"Multiple cardiovascular phenotyping - chances and options"

November 20 - Angela Maas, MD, PhD, Radboud UMC Nijmegen
"Women are not small men"

November 27 - Bas Bekkers, MD, PhD, Maastricht University Medical Center
"Cardiac magnetic resonance imaging of ischemic heart disease"

December 4 - Steven Meex, PhD, Maastricht University Medical Center
"Cardiac troponin in health and disease"

December 11 - Dobromir Dobrev, MD, PhD, University Hospital Duisburg-Essen, Germany
"Cellular and molecular mechanisms of paroxysmal AF"

Starts at 7.45 am, Academic hospital Maastricht, Meeting room A3-B3, level 3
Breakfast included! Registration not necessary
Click here for an overview of all the CGRM lectures of the fourth quarter of 2015

Symposia & events
IMCARIM seminar Dr Rafael Kramann - November 26, 2015
On Thursday November 26, the next IMCARIM lecture will be held in Aachen. Click here for more information.  Bus transportation will be organised for those who want to join the lecture. Please send an email to to register. 

Euro-CASE Annual Conference 2015 - November 2, 2015
Click here for more information

CTCM Congress 2015 - November 5, 2015
On november 5, 2015, the CTCM congress will take place at the Sint Janskerk (Vrijthof) Maastricht. The program will consist of several lectures (f.e. by Dr André Kuijpers and Prof. Mark Post) and two workshops. Click here for more information.

Presentation Theme II - November 9, 2015
Speaker: Dr Miranda Nabben, Dept. of Genetics & Cell Biology 
Title: "Cardiac metabolic adaptations in diabetic mice protect the heart from pressure overload-induced failure: a combined in vivo MRI, MRS and PET approach"
Moderator: Prof. Jan Glatz
Time and location: 12.00-13.00h, UNS 50 room 3.142A (Physiology) 

Vascular Networkshop - November 16, 2015

On Monday November 16, 2015, the 10th edition of the Vascular NetWorkshop will take place from 17.30-19.30 h in the Jo Ritzenzaal/Auditorium Brians Unlimited (Oxfordlaan 55). Click here for the program.

I’mCARIM social event - November 23, 17.00 hours
This year’s social event for PhD students will be a cocktail workshop!! For more information and registration email:

Symposium iLIFE eHealth-eDUC-eLifestyle - November 24, 2015
The iLIFE team warmly welcomes you to join us on the 24th of November for a truly interdisciplinary meeting on mobile applications in health, education and lifestyle. Click here for more information.

Young Investigator Round - December 1, 2015
The next Young Investigator Round will be held on Tuesday December 1, 2015 from 16.00-17.00 hours in UNS 50 room H3.342a (BME). This meeting is designed for PhD students for informal discussions about their research. This time, Monika Rech (Cardiology) and Anke Keijbeck (Pathology) will share their recent data.


Academic events

PhD Conferral Narendra Kumar, Thursday November 5, 2015, 12.00 hours
Supervisor: Prof. J.G. Maessen
Co-supervisors: Dr C. Timmermans, Dr S. Gelsomino
Title: "Atrial fibrillation ablation: Pitfalls and potential solutions"

PhD Conferral Leonie Pelkmans, Thursday November 12, 2015, 10.00 hours
Supervisors: Prof. J.W.M. Heemskerk, Prof. H.C. Hemker (De Facto)
Co-supervisors: Dr B. de Laat, Dr H. Kelchtermans
Title: "Innovative assays to detect bleeding and thrombotic tendencies: a focus on thrombin generation and fibrin formation"

PhD Conferral Kim Hurkens, Friday November 23, 12.00 hours
Supervisor: Prof. C.D.A. Stehouwer
Co-supervisors: Dr W.J. Mulder, Dr P.H.M. van der Kuym Dr R. Janknegt (Atrium Orbis MC Sittard)
Title: "Medication Surveillance in older patients: clinical decision support as the next step in medication safety"

PhD Conferral Alex Zwanenburg. Thursday November 19, 2015, 16.00 hours
Supervisors: Prof. T. Delhaas, Prof. B.W. Kramer
Co-supervisors: Dr T.G.A.M. Wolfs, Dr P. Andriessen (MMC)
Title: "Cerebral and cardiac signal monitoring in fetal shee with hypoxic-ischemic encephalopathy"

PhD Conferral Stef Zeemering, Thursday November 26, 2015, 10.00 hours
Supervisors: Prof. R.L.M. Peeters, Prof. U. Schotten
Co-supervisor: Dr R. Westra
Title: "Sparse Estimation; applications in atrial fibrillaton"

PhD Conferral Yvonne Oligschläger, Friday November 27, 2015, 10.00 hours
Supervisor: Prof. J. Glatz
Co-supervisor: Dr D. Neumann, Dr J.J.F.P. Luiken
Title: "Tour d'AMPK: Glycogen-cytoplasmic cycling of AMP-activated prtein kinase"


Media appearances

Koen Reesink (Dept. of BME) - het Parool, Saturday 17-10-2015: 'De ideale combinatie van mens en techniek'
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