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NORI Newsletter

By Mark Simon, Founder and Director

Nutritional Oncology Research Institute and NORI Nutraceuticals


The Loss of Senator John McCain is Tragic for Many Reasons


I will admit that I am not politically aligned with all of John McCain’s views, policy decisions and values. Senator John McCain was a great leader and representative for the core values, purpose and greatness of America. I have deep respect for Senator John McCain’s courage, integrity, morality, character, honesty, tenacity and highly value his service to this nation. America and the world has suffered an enormous loss. I hope that future politicians and statespersons will follow Senator John McCain's example of greatness and selfless service to this nation. May John McCain rest in peace and may his legacy be an inspiration for all of us to strive to be our best and serve humanity to our fullest. My heart goes out to Senator John McCain’s family, friends and associates.


I am saddened by the fact that Senator John McCain had access to the best medical care available yet he succumbed to the ravages of glioblastoma and the horrific side effects from his treatments. Perhaps I should have tried harder to reach out but it is so challenging to convince not only the cancer sufferer but the patient’s family and close friends. I have witnessed remarkable responses to glioblastoma from intravenous injections of sodium selenite. Scientific evidence demonstrates that glioblastoma multiforme (GBM) cells are highly sensitive to sodium selenite. Sodium selenite is a small water soluble molecule that efficiently crosses the blood brain barrier. It is an ideal selective chemotherapeutic agent meaning that it can target and kill cancer cells without side effects and damage to healthy cells. GBM is a highly aggressive form of cancer that originates in the brain and the cause is unknown. There are approximately 10,000 deaths per year in the US from GBM. Survival after diagnosis is 12-15 months. Conventional therapies apparently have very little effect on survival from GBM.


The loss of Senator John McCain will accelerate my efforts to bring sodium selenite forward as a potent, safe and simple treatment for GBM and virtually all forms of cancer. It is well past the time to move beyond antiquated methods for cancer treatment such as chemotherapy and radiation. Let’s move forward and embrace the power of natural medicine, nutrition and follow the preexisting science that possesses all the answers. Take the profit motive out of the equation and we will have highly effective nontoxic cancer treatments. There will be a time when a great man such as John McCain and all those suffering form cancer will survive and enjoy a high quality of life.


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Anticancer properties of sodium selenite in human glioblastoma cell cluster spheroids

Journal of Trace Elements in Medicine and Biology

Volume 44, December 2017, Pages 161-176


Glioblastoma (GBM) is the most common type of primary tumor of the central nervous system with a poor prognosis, needing the development of new therapeutic drugs. Few studies focused on sodium selenite (SS) effects in cancer cells cultured as multicellular tumor spheroids (MCTS or 3D) closer to in vivo tumor. We investigated SS anticancer effects in three human GBM cell lines cultured in 3D: LN229, U87 (O(6)-methyguanine-DNA-methyltransferase (MGMT) negative) and T98G (MGMT positive). SS absorption was evaluated and the cytotoxicity of SS and temozolomide (TMZ), the standard drug used against GBM, were compared. SS impacts on proliferation, cell death, and invasiveness were evaluated as well as epigenetic modifications by focusing on histone deacetylase (HDAC) activity and dimethyl-histone-3-lysine-9 methylation (H3K9m2), after 24h to 72h SS exposition. SS was absorbed by spheroids and was more cytotoxic than TMZ (i.e., for LN229, the IC50 was 38 fold-more elevated for TMZ than SS, at 72h). SS induced a cell cycle arrest in the S phase and apoptosis via caspase-3. SS decreased carbonic anhydrase-9 (CA9) expression, invasion on a Matrigel matrix and modulated E- and N-Cadherin transcript expressions. SS decreased HDAC activity and modulated H3K9m2 levels. 3D model provides a relevant strategy to screen new drugs and SS is a promising drug against GBM that should now be tested in GBM animal models.


Sodium Selenite Induces Superoxide-Mediated Mitochondrial Damage and Subsequent Autophagic Cell Death in Malignant Glioma Cells

Eun Hee Kim, Seonghyang Sohn, Hyuk Jae Kwon, Seung U. Kim, Min-Jung Kim, Su-Jae Lee and Kyeong Sook Choi

DOI: 10.1158/0008-5472.CAN-06-4217 Published July 2007


Copyright © 2018 Nutritional Oncology Research Institute, All rights reserved.

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