B12 and Ammonia Toxicity
I have previously blogged on the subject of vitamin B12, and why the common medical tests for determining B12 deficiency are flawed. https://nutristart.com/testing-for-vitamin-b12-2/ And, by far, my most popular blog has been on the subject of ammonia toxicity. http://nutristart.com/ammonia-toxicity-part-2/
Now, thanks to reader Jimmy Jones, I have an interesting link between the two subjects.
A serum B12 test is only accurate some of the time because our tissue level of B12 can be low, while the blood appears normal. Thus normal or high serum (blood) vitamin B-12 levels can sometimes be seen in a B-12 deficient state, and can therefore be misleading. Better indicators of B-12 deficiency than the actual serum B-12 level itself are tests which indicate high levels of Methymalonic Acid (MMA) and/or Homocysteine (HC). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725715/
MMA is generally elevated in 90-98% of patients with B12 deficiency (at the mitochondrial level) and reflects functional deficiency of vitamin B12. http://www.homerton.nhs.uk/5429.aspx
Furthermore, when B12 gets too low, it causes methylmalonic acid to rise dangerously, blocking enzymes in the urea cycle that convert ammonia into urea. This in turn leads to elevated ammonia levels. Most doctors are unaware that low B12 causes high ammonia, and they often misdiagnose people with other conditions. http://www.oaanews.org/what-we-know-about-ammonia-in-organic-acidemias.html
PREVENTING EXERCISE INDUCED JOINT DISCOMFORT
We at Nutristart use NEM, an eggshell membrane extract scientifically proven to treat symptoms of osteoarthritis, in our JointStart Supreme product. http://nutristart.com/products/jointstart-supreme/
A new study done on NEM (published in the Journal Clinical Interventions in Aging) has shown it to also have fast benefits for exercise-induced joint discomfort. This study was designed to evaluate whether NEM® (natural eggshell membrane) would reduce exercise-induced cartilage turnover, or alleviate joint pain or stiffness, either directly following exercise or 12 hours post exercise (versus placebo).
"NEM, 500 mg once daily, rapidly improved recovery from exercise-induced joint pain (Day 8) and stiffness (Day 4) and also significantly reduced the discomfort from stiffness immediately following exercise (Day 7). Moreover, a substantial chondroprotective effect was demonstrated from supplementation with NEM through a lasting decrease in the cartilage degradation process." http://www.ckingredients.com/pdf/f_CIA-153782-beneficial-effects-of-natural-eggshell-membrane--nem--versu.._.pdf?a2_cs_key=2566224
This would indicate that, given the extra anti-inflammatory and cartilage rebuilding substances found in Jointstart Supreme, our product would be extremely helpful in dealing with exercise-induced stiffness, pain, inflammation, and joint deterioration.