Statement by the ECHO Management Committee
on the new WHO guidance on use of hormonal contraceptives
by women at high risk of HIV
3 March 2017 – Injectable progestogens are the most widely used contraceptives in sub-Saharan Africa, including in countries with high HIV prevalence.  On 2 March 2017, the World Health Organisation (WHO) released revised guidance on the use of hormonal contraceptives by women at high risk of HIV infection. The WHO reviewed the available evidence and graded the information as “low-to-moderate” quality. They concluded that “there continues to be evidence of a possible increased risk of HIV among progestogen-only injectable users” and that “uncertainty exists about whether this is due to methodologic issues with the evidence or a real biologic effect”. The WHO recommends that long-acting progestogen-only injectables (DMPA and NET-EN) should remain accessible to women at high risk of HIV, “because the advantages of these methods generally outweigh the possible increased risk of HIV acquisition.” However, women at high risk of HIV who choose to use these methods should be counselled about the possible increased risk of HIV and how to reduce this risk.
The WHO recommendations are strongly rooted in women’s right to accurate information enabling them to make informed choices about their contraceptive methods. Women should have full access to the methods of their choice, regardless of their HIV risk. All women using contraceptive methods should be advised of ways to reduce their risk of acquiring HIV and other STIs. The WHO guidance highlights the continued importance of randomised clinical trials to clarify whether or not there is a causal relationship between use of progestogen injectables and an increased risk of acquiring HIV.
The ECHO Study (Evidence for Contraceptive Options and HIV Outcomes), launched in December 2015, is the first randomised clinical trial designed to assess the risk of HIV acquisition by women using three contraceptive methods:  the progestogen injection DMPA, the levonorgestrel implant Jadelle and the non-hormonal copper IUD. The study will also evaluate the performance of these methods in relation to pregnancy rates, side effects and women’s patterns of use. The Study has already enrolled over half of the intended 7 800 voluntary participants at 12 research sites in Kenya, South Africa, Swaziland and Zambia and is expected to yield results in early 2019. The ECHO Study will contribute important evidence to family planning programmes and policy makers on DMPA, the Jadelle implant and the copper IUD. By filling important information gaps, ECHO will provide more information to policymakers, health care providers and women users about these three contraceptive methods.
Following the release of WHO’s new guidance, the independent Data Safety and Monitoring Board (DSMB) that oversees the ECHO study, reviewed study progress focusing on safety and data quality, as well as considering the implications of the WHO guidance for the study. The DSMB recommended the continuation of the ECHO study.  

As the study goes forward, the ECHO research team will ensure that current participants receive an information sheet explaining the updated WHO guidance. All recruitment and informational material, as well as counselling messages for current participants, will be similarly updated. The revised study protocol and materials will be reviewed by the ethical review committees overseeing ECHO. 
The ECHO study is committed to conducting the trial to the highest possible standards, including information on PrEP as part of the prevention package where appropriate, in order to produce reliable, useful findings. In this way, ECHO will answer reproductive health questions that are of critical importance to millions of women.
The ECHO Management Committee
Jared Baeten, Professor, Schools of Medicine and Public Health, University of Washington, United States
Timothy Mastro, Chief Science Officer, FHI 360, United States
Nelly Mugo, Head, Sexual, Reproductive, Adolescent and Child Health Research Programme, Kenya Medical Research Institute
Helen Rees, Executive Director, Wits RHI & Personal Professor, Obstetrics and Gynaecology, University of the Witwatersrand, South Africa
For more information on the ECHO Study or the WHO’s new guidance, please see these links to resources:
  • ECHO Questions and Answers – dated 3 March 2017:
  • WHO guidance statement: Hormonal contraceptive eligibility for women at high risk of HIV at
  • WHO frequently asked questions on hormonal contraceptive eligibility for women at high risk of HIV at
  • AVAC has prepared a plain language fact sheet on injectable contraceptives and WHO family planning “grades” – “What’s up with DMPA and “grades for family planning?” – at
Copyright © 2017 ECHO Comms Team, All rights reserved.

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