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         Vol. 3, No. 25                                                                                                 December 16, 2020

Cancer Institute Member Spotlight

Kristin K. Zorn, M.D.

Professor, Department of Obstetrics and Gynecology
Associate Professor, Division of Genetics
Director, Division of Gynecologic Oncology
Director, Hereditary Gynecologic Cancer Clinic
Acting Director, Adult Cancer Genetics
Associate Director for Clinical Research, Winthrop P. Rockefeller Cancer Institute

Dr. Zorn's research focuses on increasing access to genetic counseling and testing so that we can be proactive about management of inherited cancer risk. Read more>
TRI Now Seeking Applicants for 2021 KL2 Awards
The UAMS Translational Research Institute (TRI) is pleased to invite full applications for the 2021 KL2 Mentored Research Career Development Scholar Awards. KL2 Scholar Awards are part of the TRI Career Development Scholars Program which provides support for early-career UAMS faculty with a professional degree (M.D., Ph.D., Pharm.D., D.N.P., Dr.PH., D.O., etc.) who are committed to an academic career in multidisciplinary clinical or translational research. 

The two-year program of intensive training combines an innovative educational program with mentored clinical/translational science research. KL2 Scholars are funded by the Clinical and Translational Science Award (CTSA) Program and will receive:
•    Salary support/stipend of up to $95,000 (including fringe) per year. 
•    Up to $25,000 of non-salary support per year, which can be used for research, tuition, travel expenses, educational materials and other costs related to the scholar’s research.
The 2021 KL2 opportunity includes a Cancer Research Institutional Scholar Award, funded by the UAMS Winthrop P. Rockefeller Cancer Institute.

An informational session will be held via Zoom on January 14 at 1 p.m. More information is available on the TRI calendar. 

View the Request for Applications document.


Important Dates:
January 14, 2021, KL2 Scholar Awards Informational Session, 1 – 2 p.m.
February 1, 2021, by 4:00 p.m.: Letter of Intent (LOI) due (non-binding)
February 26, 2021, Required Pre-Reviews and Authorizations Due 
March 12, 2021, by 4:00 p.m., Proof of regulatory submission
March 19, 2021, by noon, Full applications due
May 3, 2021: Awardees notified
July 1, 2021: KL2 start date and earliest possible project start date
Jeannette Y. Lee, Ph.D., on Committee
To Review COVID-19 Vaccines
Jeannette Y. Lee, Ph.D., Cancer Institute member and professor in the Department of Biostatistics, recently reviewed and voted on FDA approval of the Pfizer vaccine to prevent COVID-19.

Lee serves as a temporary voting member on the FDA Vaccine and Related Biological Products Advisory Committee, which is reviewing applications for Emergency Use Authorization (EUA) for vaccines to prevent COVID-19. The FDA considers the committee’s recommendations in making its final recommendations for an EUA.  

As more information becomes available, vaccine manufacturers are expected to submit applications for Biological License Authorization, which would mean full licensure for these products.

Lee also will participate in the review of the Moderna vaccine on Dec 17.
2020 Research Wrap-up
As 2020 draws to a close, we look back on a year of research achievements at the Winthrop P. Rockefeller Cancer Institute:

The fourth annual Proteomics Facility Staff Symposium  brought together 30 proteomics core directors and staff members to learn how best to operate and maintain these facilities at their institutions.

A team led by UAMS cancer researcher Valentina Todorova, Ph.D., published their study titled “Dantrolene Attenuates Cardiotoxicity of Doxorubicin Without Reducing its Antitumor Efficacy in a Breast Cancer Model” in Translational Oncology.

Three Seeds of Science small grant awards of $50,000 each were presented March 5 to UAMS cancer researchers at “The Doctor is in” event hosted by the Envoys volunteer advocacy group.

Fen Xia, M.D., Ph.D., received a $1.86 million NCI grant for her project titled “The Novel Role of Sirtuin 2 in Regulation of Transcription-Associated DNA Damage Repair.”

A research team led by Justin Leung, Ph.D., published their study titled “Histone H2A variants alpha1-extension helix directs RNF168-mediated ubiquitination” in the open-access journal Nature Communications.

A four-year grant of $894,074 to Fred Prior, Ph.D., gave UAMS a key role in an international effort using artificial intelligence to teach computers at local research centers how to recognize cancer.

The Cancer Institute announced the addition of 12 new oncologists.

A national database for patient cancer images at UAMS became the storage site for COVID-19 clinical images from across the United States and around the globe, including chest x-rays and CT scans of the body.

Fenghuang “Frank” Zhan, M.D., Ph.D., received two grants totaling almost $3.14 million to study the molecular genetics and drug resistance of multiple myeloma.

Analiz Rodriguez, M.D., Ph.D., received a $25,000 grant to further her gene expression research using targeted software.

The Radiation Oncology Residency program received accreditation from the Accreditation Council for Graduate Medical Education.

A $780,000 NCI grant to Tom Kelly, Ph.D., and Richard Nicholas, M.D., will fund a hands-on summer cancer research experience for medical students at UAMS.

A $10.6 million NIH grant to Alan Tackett, Ph.D., established the IDeA National Resource for Quantitative Proteomics as the first NIH National Resource in Arkansas.

Donald J. Johann, M.D., played an integral role in the publication of research by the Blood Profiling Atlas in Cancer Consortium (BloodPAC) related to liquid biopsies.

Led by Marjan Boerma, Ph.D., UAMS researchers received a five-year $11.4 million COBRE grant to continue research into the side effects of cancer therapies.

“Be a Part of the Cure,” the Cancer Institute’s first-ever televised fundraising event, raised more than $400,000 for research and treatment programs.

Justin Leung, Ph.D., received a five-year, $1.9 million NIH grant to advance his research of DNA damage response in cancer and genetic disorders.

Jesus Delgado-Calle, Ph.D., was awarded a $1.7 NCI million grant to study bone health in myeloma patients.

The University of Arkansas Board of Trustees approved joint ventures between UAMS, Baptist Health and Arkansas Children’s to expand access to radiation therapy, as well as establish the state’s first proton therapy center.

More than 160 scientists gathered online Oct. 30 for the first-ever UAMS – UA Fayetteville Collaborative Cancer Research Retreat.

The Cancer Institute opened a new infusion center that includes Arkansas’ first Phase I cancer clinical trial unit.
Cancer-related Research Funding Opportunities
Extramural Opportunities
Collaborative Approaches to Engineer Biology for Cancer Applications (U01 Clinical Trial Not Allowed)

Integrating Biospecimen Science Approaches into Clinical Assay Development

Secondary Analysis and Integration of Existing Data to Elucidate the Genetic Architecture of Cancer Risk and Related Outcomes (R01 Clinical Trial Not Allowed)

Secondary Analysis and Integration of Existing Data to Elucidate the Genetic Architecture of Cancer Risk and Related Outcomes (R21 Clinical Trials Not Allowed)

Advancing Research to Develop Improved Measures and Methods for Understanding Multimorbidity (R01 Clinical Trial Optional)

Identifying Innovative Mechanisms or Interventions that Target Multimorbidity and Its Consequences (R01 Clinical Trial Optional)

Research to Reduce Morbidity and Improve Care for Pediatric, and Adolescent and Young Adult (AYA) Cancer Survivors (R01 Clinical Trial Optional)

Strengthening Institutional Capacity to Conduct Global Cancer Research in Low- and Middle-Income Countries (D43 Clinical Trial Not Allowed)

Multilevel Interventions in Cancer Care Delivery: Follow-up to Abnormal Screening Tests
Using Information Technology to Support Systematic Screening and Treatment of Depression in Cancer (R01)

Using Information Technology to Support Systematic Screening and Treatment of Depression in Cancer (R21)

Linking the Provider Recommendation to Adolescent HPV Vaccine Uptake (R01 Clinical Trial Optional)

Linking the Provider Recommendation to Adolescent HPV Vaccine Uptake (R21 Clinical Trial Optional)

Linking the Provider Recommendation to Adolescent HPV Vaccine Uptake (R03 Clinical Trial Optional)

Increasing Uptake of Evidence-Based Screening in Diverse Adult Populations (R01 Clinical Trial Optional)

Intervening with Cancer Caregivers to Improve Patient Health Outcomes and Optimize Health Care Utilization (R01 Clinical Trial Optional)

Intervening with Cancer Caregivers to Improve Patient Health Outcomes and Optimize Health Care Utilization (R21 Clinical Trial Optional)

New Cohorts for Environmental Exposures and Cancer Risk (CEECR; UG3/UH3 Clinical Trial Not Allowed) Synopsis

New Cohorts for Environmental Exposures and Cancer Risk (CEECR) Coordinating Center (U24 Clinical Trial Not Allowed) Synopsis 1

Collaborative Approaches to Engineer Biology for Cancer Applications (U01 Clinical Trial Not Allowed)

Collaborative Approaches to Engineer Biology for Cancer Applications (U01 Clinical Trial Not Allowed)

DOD Prostate Cancer, Physician Research Award

New Informatics Tools and Methods to Enhance U.S. Cancer Surveillance Research (U01 Clinical Trial Optional)


CTSA Supplemental Funding Opportunities

Limited Competition: Clinical and Translational Science Award (CTSA) Program: Exploratory Collaborative Innovation Awards (R21 Clinical Trial Optional)

Limited Competition: Clinical and Translational Science Award (CTSA) Program: Collaborative Innovation Award, (U01 Clinical Trial Optional)

Foundation and Intramural Funding Opportunities
Development Enhancement Awards for Proposals

Faculty Research Enhancement Awards

American Society of Clinical Oncology – Women Who Conquer Cancer Mentorship Awards

American Society of Clinical Oncology – Long-term International Fellowship

Interprofessional Education Small Grant Program
 

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Copyright © 2020 UAMS Winthrop P. Rockefeller Cancer Institute, All rights reserved.


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